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BG Medicine Welcomes La Jolla Pharmaceutical Company's Announcement Of Positive Top-Line Results Of Phase 2 Clinical Trial Of Novel Pharmaceutical Compound Targeting Galectin-3 In Chronic Kidney Disease

WALTHAM, Mass., March 12, 2014 (GLOBE NEWSWIRE) -- BG Medicine, Inc. (Nasdaq:BGMD) welcomed today an announcement by La Jolla Pharmaceutical Company (LJPC) on March 10, 2014 of positive top-line results of its randomized, placebo-controlled Phase 2 trial of the galectin-3 inhibitor compound GCS-100 in chronic kidney disease. The trial met its primary efficacy endpoint of improvement in kidney function, as well as key secondary endpoints including a statistically significant reduction in circulating levels of galectin-3, the molecular target of GCS-100, at the effective therapeutic dose, as measured using the BGM Galectin-3 ® Test.

The U.S. National Institutes of Health and the National Institute of Diabetes and Digestive and Kidney Diseases have noted that recent research has provided important insights into the origins of fibrosis and scar tissue formation that is seen in some forms of kidney disease. [1] In the kidney, the process of fibrosis is a common pathway for many diseases. [1] In previous studies, galectin-3 has been demonstrated to be a biomolecular mediator of the processes of fibrosis and inflammation, and in animal models, inhibition of galectin-3 has been shown to improve conditions associated with organ fibrosis. [2,3,4].

"We welcome the important clinical science that this Phase 2 trial represents," said Dr. Paul R. Sohmer, President and CEO of BG Medicine, Inc. "We look forward to the continued advancement of the fundamental science on the biological role of galectin-3 in health and disease."

The BGM Galectin-3® Test is cleared by the U.S. FDA as an aid in assessing the prognosis of patients diagnosed with chronic heart failure when used in conjunction with clinical evaluation.

The BGM Galectin-3® Test is CE Marked and is available in Europe as an aid in assessing the prognosis of patients diagnosed with acute and chronic heart failure when used in conjunction with clinical evaluation. It is also CE Marked for adults as an aid in assessing the risk of new onset heart failure.

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