This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Presentation And Publication Of Research At AAAAI Demonstrates EPIT(TM)'s Ability To Rebalance The Immune System And Induce A Disease-Modifying Effect

BAGNEUX, France, March 4, 2014 (GLOBE NEWSWIRE) -- DBV Technologies (Euronext: DBV - ISIN: FR0010417345), creator of Viaskin®, a new paradigm for the treatment of allergies, today announced that further preclinical data supporting Epicutaneous Immunotherapy's (EPIT TM ) immune-modulating long-lasting and protective effect were presented at the 2014 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI) and recently published in the Journal of Allergy and Clinical Immunology ("State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous"; Stacie M. Jones, A. Wesley Burks, and Christophe Dupont; JACI, February 2014, Volume 133, Number 2).

Pierre-Henri Benhamou, Chairman & CEO of DBV Technologies, said: " DBV is developing Viaskin, a first-in-class treatment for IgE-mediated allergies, which will probably revolutionize the way allergic diseases are currently treated. Viaskin's excellent acceptability, efficacy and safety profile, which does not require oral intake of the offending allergen will help to treat food allergic patients with a pharmaceutical treatment that is safe even for the most vulnerable and the youngest patients. Dr. Benhamou concluded "In our effort to continue expanding our understanding of EPIT's mechanism of action, these new data will extend our knowledge on the long term efficacy and tolerance induction process. We are especially proud of the Dr. Mondoulet's findings on epigenetic level and of the report from Dr. Cecilia Berin, worldwide recognize searcher in allergy from Mount Sinai Hospital, NY, who brings new evidence of the long term efficacy of Viaskin."

Summary from AAAAI 2014 Presentations and Recent Scientific Publications

Epicutaneous immunotherapy (EPIT) will allow to treat safely life-threatening allergies in highly sensitive patient population, such as the pediatric patients. Recent preclinical data and scientific publications suggest:

EPIT TM delivers a powerful and long lasting immune-modulating and protective effect, directly in the genome evidenced through epigenetic changes observed by Dr. Mondoulet. This mechanism results to a long term protection and prevent new sensitization via a T cell regulatory (Treg) in an animal model. Compared to SLIT (sublingual immune therapy), EPIT induces a larger and stronger expression of T cell regulatory (Treg). In another study presented at San Diego, Tregs induced by EPIT have a digestive tropism explaining the effectiveness of EPIT in food allergy.

A recent scientific publication in the Journal of Allergy and Clinical Immunology (JACI), "State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous", also recently underlined the novel and differentiated cellular mechanism of EPIT TM in comparison with the other methods of desensitization. While the clinical program is ongoing, DBV continues to support its scientific research in order to fully elucidate the underlying immune mechanisms of food allergy and of tolerance induction.

About DBV Technologies

DBV Technologies is opening up a decisive new approach to the treatment of allergy - a major public health issue that is constantly increasing in prevalence. Food allergies represent a true handicap in everyday life for millions of people and thus constitute a major unmet medical need. DBV Technologies has developed a unique, proprietary, worldwide-patented technology for administering an allergen to intact skin and avoiding massive transfer to the blood. The Viaskin® technology combines efficacy and safety as part of a treatment that seeks to improve the patient's tolerability of peanut and thus considerably lower the risk of a systemic, allergic reaction in the event of accidental exposure to the allergen. The company's significant development program has taken this revolutionary method through to the industrial stage in Europe, initially. The product's clinically proven safety of use enables the application of effective desensitization techniques (the efficacy of which is acknowledged worldwide) in the most severe forms of the allergy. DBV Technologies is focusing on food allergies (milk and peanut) for which there are currently no effective treatments. It has developed two products: Viaskin® Peanut and Viaskin® Milk. The clinical development program for Viaskin® Peanut has received Fast Track designation from the US Food and Drug Administration. The company will subsequently develop a Viaskin® patch for young children with house dust mite allergy - a true public health issue because this pathology is one of the main risk factors for childhood asthma. DBV Technologies shares are traded on segment C of Euronext Paris (Ticker: DBV, ISIN code: FR0010417345). For more information on DBV Technologies, please visit our website: www.dbv-technologies.com

CAUTION: Viaskin® is not approved for sale in the USA.

1 of 2

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 17,172.68 -107.06 -0.62%
S&P 500 1,994.29 -16.11 -0.80%
NASDAQ 4,527.6890 -52.10 -1.14%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs