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Myriad Publishes Clinical Utility Study For Prolaris(R)

Stocks in this article: MYGN

SALT LAKE CITY, March 3, 2014 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (Nasdaq:MYGN) today announced that it has published data from the PROCEDE 500 study in the journal Current Medical Research and Opinion, demonstrating that 65 percent of physicians changed their original treatment plans for men with prostate cancer based on results from the Prolaris test. Prolaris is a 46-gene molecular diagnostic test that has been evaluated in 11 clinical studies with more than 5,000 patients.

"Prolaris is an absolute game changer for urologists because it adds meaningful new prognostic information in terms of risk assessment for prostate cancer patients that will improve their care," said E. David Crawford, M.D., head of the Section of Urologic Oncology at the University of Colorado. "In this study, Prolaris led to major changes in therapies with significant reductions or increases in interventional treatments that were based on patients' unique risk profiles."

PROCEDE 500 is a prospective registry study that was designed to evaluate the impact of the Prolaris test on physician treatment recommendations for patients with prostate cancer. In this study of 305 patients, physicians said they would change their treatment plans in 65 percent of cases after receiving the Prolaris report – 40 percent of patients had a reduction in therapeutic burden, while 25 percent had an increase in therapeutic burden – independent of treatment strategy (i.e., surgery and/or radiation vs. active surveillance and/or watchful waiting). These results are summarized in Table-1 and Table-2 below:

Table – 1: Reduction in Therapeutic Burden Among Trial Participants

 
Number of Patients in the Study Number of Patients Who Saw a Reduction in Therapeutic Burden Percentage Decrease in Therapeutic Burden
305 122 -40%

Table – 2: Increase in Therapeutic Burden Among Trial Participants

 
Number of Patients in the Study Number of Patients Who Saw an Increase in Therapeutic Burden Percentage Increase in  Therapeutic Burden
305 76 +25%

The study also evaluated the shift in treatment paradigms from interventional to non-interventional and non-interventional to interventional. Those data appear in the Table-3 and Table-4 below:

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