SALT LAKE CITY, Feb. 18, 2014 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (Nasdaq:MYGN) today announced it has published data in the Journal of Urology demonstrating that its Prolaris test accurately predicted, based on biopsy specimens, which men would develop biochemical recurrence (BCR) or metastatic disease following radical prostate surgery. Prolaris is a 46-gene molecular diagnostic test that has been evaluated in more than 5,000 patients across 11 clinical studies.
"This study represents a great advance in the treatment of prostate cancer. The results from three different institutions show that Prolaris can better define patient prognosis and improve care," said Jay T. Bishoff, M.D., director of the Intermountain Urological Institute, at Intermountain Health Care and a study investigator. "Having a test that identifies which patients are likely to fail surgery is a big clinical advantage for physicians. Patients with a low score may be candidates for active surveillance, while patients with a high score indicative of aggressive cancer, may benefit from more intensive medical treatments."
The study evaluated biopsy specimens in 582 men who were treated by radical prostatectomy. In the study, biopsy samples were evaluated from three cohorts of contemporary patients in the United States and Germany. The clinical endpoints were metastatic disease and BCR. In all cohorts, the Prolaris test was a statistically significant predictor of BCR and was the single strongest predictor of metastatic disease when compared to Gleason Score or PSA. In the pooled analysis, each one-unit increase in the Prolaris score translated into a fivefold increased risk of metastases and a 1.6-times increased risk of BCR."Men newly diagnosed with prostate cancer are often treated by radical prostatectomy, and about 30 percent of these patients will have metastases or progress even after surgery," said Michael Brawer, M.D., vice president of medical affairs at Myriad Genetic Laboratories. "The Prolaris test answers an important clinical question for all urologists concerning their surgical candidates…do my patients have an aggressive prostate cancer or not and therefore need more aggressive treatment?"
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