This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Ampio Announces Positive Preliminary Biochemical Findings From The Synovial Fluid Of The Knees Treated In The SPRING Study

Stocks in this article: AMPE





GREENWOOD VILLAGE, Colo., Feb. 13, 2014 /PRNewswire/ -- Ampio Pharmaceuticals, Inc. (NYSE MKT: AMPE) today announced preliminary biochemical analysis of samples of synovial fluid drawn from the index knee (treated knee) of a subset of patients who participated in the SPRING study. This synovial analysis, suggested by the FDA, tests the change in expression of signaling and structural proteins that arise from the treatment of the knee with either Ampion TM or the saline vehicle control.  Proteins are vital parts of living organisms, as they are the main components of the metabolic pathways of cells. 

(Logo: http://photos.prnewswire.com/prnh/20120516/MM09116LOGO)

Dr. David Bar-Or, Ampio's Chief Scientific Officer, explained, "These patients received injections of either saline or Ampion™ and samples of their synovial fluid were collected at baseline and 12 weeks post treatment and analyzed by an independent laboratory using proteomic tools. Proteomic analysis provides a large-scale study of proteins, particularly their structure and function. Although the patient subset was small, we identified twenty (20) proteins that showed significant differences in the expression of certain proteins between the saline and Ampion™ groups. Thirteen (13) proteins involved with healing, mesenchymal stem cell protection, mobilization of stem cells and cartilage remodeling were up regulated (increased) in the Ampion™ treated knees synovial fluid compared to the saline ones. Seven (7) other proteins that are pro-inflammatory kinases were down regulated (decreased) by Ampion™ compared to saline."

"In addition," Dr. Bar-Or continued, "Magnetic Resonance Imaging (MRI) tests conducted on a subset of patients before and after treatment (baseline and 12 weeks) demonstrated an effect on the sub-chondral region (the bone under the cartilage) in patients receiving Ampion TM compared to saline, possibly indicating the recruitment of stem cells from the adjacent bone marrow."

"This analysis of SPRING study patient synovial fluid has been expanded in the STEP study along with a further MRI analysis of index knees.  Combined with the company's In Vitro studies of the effect of Ampion TM on immune cells and mesenchymal stem cells, a comprehensive analysis of the mechanism-of-action (MOA) of Ampion TM will be compiled and presented to peer reviewed scientific journals for publication."

Michael Macaluso, Ampio's CEO, noted that "We are pleased that the preliminary results support, and provide a basis for, the reduction of pain reported in the SPRING study.  We look forward to receiving the proteomic and MRI data for presentation later in the year."

About Ampio PharmaceuticalsAmpio Pharmaceuticals, Inc. is a development stage biopharmaceutical company primarily focused on the development of therapies to treat prevalent inflammatory conditions for which there are limited treatment options. We are developing compounds that decrease inflammation by (i) inhibiting specific pro-inflammatory compounds by affecting specific pathways at the protein expression and at the transcription level; (ii) activating specific phosphatase or depletion of the available phosphate needed for the inflammation process; and (iii) decreasing vascular permeability.

Forward Looking StatementsAmpio's statements in this press release that are not historical fact and that relate to future plans or events are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by use of words such as "believe," "expect," "plan," "anticipate," and similar expressions. These forward-looking statements include risks associated with clinical trials, expected results, regulatory approvals, and changes in business conditions and similar events. The risks and uncertainties involved include those detailed from time to time in Ampio's filings with the Securities and Exchange Commission, including without limitation, under Ampio's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q.  Ampio undertakes no obligation to revise or update these forward-looking statements, whether as a result of new information, future events or otherwise. 

Investor & Media Contact: April RamirezAmpio Pharmaceuticals, Inc.Direct: (720) 437-6500Email: aramirez@ampiopharma.com 

SOURCE Ampio Pharmaceuticals, Inc.

Copyright 2011 PR Newswire. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!

Markets

DOW 18,053.71 +23.50 0.13%
S&P 500 2,088.77 +6.89 0.33%
NASDAQ 4,806.8590 +33.3870 0.70%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs