"OMP-54F28 combined with Abraxane and gemcitabine demonstrates potent and sustained anti-tumor activity as well as anti-CSC activity in preclinical patient-derived pancreas cancer xenograft models. We are eager to explore whether these findings can be translated into the clinic as we embark on this important step of evaluating safety, biomarkers, and efficacy of OMP-54F28 in combination with standard-of-care chemotherapy in patients with metastatic pancreatic cancer," said Jakob Dupont, M.D., Chief Medical Officer of OncoMed.This first Phase 1b study for OMP-54F28 will be followed shortly by two additional Phase 1b studies. Interim results for the single-agent, first-in-human Phase 1a trial for OMP-54F28 in solid tumor patients were recently presented at the 2013 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston. Results from the Phase 1a study showed that OMP-54F28 is well tolerated and modulates the Wnt pathway starting at low doses, as evidenced by PD biomarker analysis of hair follicles. OncoMed recently initiated Phase 1b studies for its other Wnt-pathway-targeting product candidate, vantictumab, in HER2-negative breast cancer, non-small cell lung cancer and pancreatic cancer.
OncoMed Pharmaceuticals Initiates First Phase 1b Clinical Trial Of OMP-54F28 (Fzd8-Fc) With Nab-Paclitaxel (Abraxane(R)) And Gemcitabine In Pancreatic Cancer
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