This Day On The Street
Continue to site
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Immunomedics Announces U.S. Patent For Antibody-SN-38 Conjugates

MORRIS PLAINS, N.J., Dec. 31, 2013 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced the issuance of U.S. patent no. 8,617,558 for additional claims under the patent family "Camptothecin-binding moiety conjugates," and U.S. patent no. 8,617,518 with additional claims for the patent family "Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules."

Patent 8,617,558 relates to our proprietary linker technology for conjugating SN-38 to the Company's humanized antibodies for targeted delivery of the potent drug to the tumor. The patent will expire in December 2023. Additional patents covering the Company's antibody-drug conjugates are being prosecuted in major countries worldwide.

"This is a key patent for the protection of our antibody-drug conjugates patent family, of which IMMU-132, an anti-TROP-2-SN-38 conjugate, and IMMU-130, an anti-CEACAM5-SN-38 conjugate, constitute two of our most exciting new agents for solid cancer therapy," commented Cynthia L. Sullivan, President and Chief Executive Officer. "Both IMMU-132 and 130 are in Phase II clinical development and we plan to report results from these studies in the second quarter of 2014 at upcoming scientific and medical conferences."

In early dose-escalation studies, the two antibody-SN-38 conjugates have shown evidence of tumor shrinkage in patients with difficult-to-treat solid tumors who had failed multiple prior therapies, including irinotecan.

SN-38 is the active metabolite of irinotecan, a camptothecin analogue approved for the treatment of metastatic colorectal cancer. While SN-38 is 2 to 3 orders of magnitude more potent than its parent molecule, it does not dissolve in water and cannot be administered directly to patients. Our unique linker allows us to produce antibody-SN-38 conjugates that are soluble in water with excellent yields, as well as preservation of antibody binding and drug activity, even after attaching about 7 drug molecules per antibody.

1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
SYM TRADE IT LAST %CHG

Markets

Chart of I:DJI
DOW 16,093.86 -434.17 -2.63%
S&P 500 1,924.50 -47.68 -2.42%
NASDAQ 4,671.4620 -105.0460 -2.20%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs