This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Spectrum Pharmaceuticals Highlights Encouraging FOLOTYN® And MARQIBO® Clinical Data Presented At The 55th Annual Meeting Of The American Society Of Hematology (ASH)

Stocks in this article: SPPI

Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biotechnology company with fully integrated commercial and drug development operations with a primary focus in hematology and oncology, today announced encouraging clinical data from investigator-sponsored studies of MARQIBO® (vinCRIStine sulfate LIPOSOME injection) and FOLOTYN® (pralatrexate injection).

“At the ASH meeting there were several presentations on our drugs and we are especially excited about two,” said Rajesh C. Shrotriya, M.D., Chairman, President and Chief Executive Officer of Spectrum Pharmaceuticals, Inc. “Data from Marqibo’s Phase 2 study suggests the drug potentially could have utility in the treatment of Diffuse Large B-cell Lymphoma (DLBCL), in the front-line setting. DLBCL is a disease with a poor prognosis and better treatments are needed to improve outcomes for these patients. These data reinforce our excitement in Marqibo’s continuing development strategy, which currently includes the ongoing investigator-initiated Phase 3 Optimal>60 trial being conducted by the German High-Grade NHL Study Group in the same patient population. The second abstract provides data on the use of Folotyn as front-line therapy in patients with Peripheral T-cell Lymphoma (PTCL). These findings suggest that Folotyn may provide benefit to patients with early stage disease, a setting that we are currently exploring in a large Phase 3 study.”

Select ASH Presentation Summaries

Following are summaries of key presentations at ASH:

Abstract # 3033 - Long Term Results Of a Phase 2 Study Of Vincristine Sulfate Liposome Injection (Marqibo®) Substituted For Non-Liposomal Vincristine In CHOP With Or Without Rituximab For Patients With Untreated Aggressive Non-Hodgkin’s Lymphomas

This study evaluated 60 patients with untreated DLBCL in which Marqibo was substituted for Vincristine (VCR) in R-CHOP creating R-CHMP. The primary endpoint was overall response rate (ORR), and secondary endpoints were Progression free survival (PFS) and overall survival (OS). The overall response rate was 95% (57/60) and the complete response rate (CR) was 90% (54/60). Ten year PFS and OS were 64% and 87%, respectively. In patients greater than 60 years of age, overall response rate was 91%, 10 year PFS= 48%, and 10 year OS was 65%. The safety profile of R-CHMP was comparable to what has been reported in the literature for R-CHOP. Grade 3 peripheral neuropathy was 3%. The authors concluded that the R-CHMP “resulted in a high ORR and encouraging PFS and OS without apparent increased toxicity compared to historical experience with R-CHOP. In particular, elderly DLBCL patients with an unfavorable prognosis, based on age-adjusted International Prognostic Index (aaIPI) experienced remarkable PFS and OS.”

1 of 9

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 16,712.36 +251.04 1.52%
S&P 500 1,953.89 +26.78 1.39%
NASDAQ 4,455.7190 +72.8720 1.66%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs