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Siltuximab Pivotal Trial Data Show Efficacy For Treatment Of Patients With Multicentric Castleman's Disease

Janssen Research & Development is part of the Janssen Pharmaceutical Companies. Please visit http://www.janssenrnd.com for more information.

References:                                        

1 Wong RS et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Of The Efficacy and Safety Of Siltuximab, An Anti-Interleukin-6 Monoclonal Antibody, In Patients With Multicentric Castleman's Disease. Oral presentation presented at: 55 th American Society of Hematology (ASH) Annual Meeting; Dec. 7-11, 2013; New Orleans, LA.   

2 American Cancer Society. What is Castleman disease? Available from: http://www.cancer.org/cancer/castlemandisease/detailedguide/castleman-disease-what-is-castleman-disease. Accessed August 2013

3 Memorial Sloan Kettering Cancer Center. Uncommon Lymphoproliferative Disorders. Available from: http://www.mskcc.org/cancer-care/adult/rare-hematologic-disorders/uncommon-lymphoproliferative-disorders. Accessed August 2013.

4 Van Rhee F et al. An Open-Label, Phase 2, Multicenter Study Of The Safety Of Long-Term Treatment With Siltuximab (an Anti-Interleukin-6 Monoclonal Antibody) In Patients With Multicentric Castleman's Disease. Poster presentation presented at: 55 th American Society of Hematology (ASH) Annual Meeting; Dec. 7-11, 2013; New Orleans, LA.   

5 American Cancer Society. How is Castleman disease diagnosed? Available from: http://www.cancer.org/cancer/castlemandisease/detailedguide/castleman-disease-diagnosis Accessed October 2013

6 El-Osta HE, Kurzrock R. Castleman's disease: from basic mechanisms to molecular therapeutics. Oncologist. 2011;16(4):497-511.

7 Peterson, B. Seminars in Oncology. Multicentric Castleman's disease. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8296200  Accessed October 2013

8 Greiner, T.  Hematology Am Soc Hematol Educ Program. Atypical Lymphoproliferative Diseases. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11701539 Accessed October 2013

9 National Center for Advancing Translational Sciences. Multicentric Castleman's Disease. Available from: http://rarediseases.info.nih.gov/gard/9644/idiopathic-multicentric-castlemans-disease/resources/1 Accessed November 2013.

10 American Cancer Society. Treatment of localized (unicentric) Castleman disease. Available from: http://www.cancer.org/cancer/castlemandisease/detailedguide/castleman-disease-treating-treating-localized. Accessed October 2013

11 American Cancer Society. Treatment of multicentric Castleman disease. Available from: http://www.cancer.org/cancer/castlemandisease/detailedguide/castleman-disease-treating-treating-multicentric. November October 2013

12  American Cancer Society. What are the key statistics about Castleman disease? Available from: http://www.cancer.org/cancer/castlemandisease/detailedguide/castleman-disease-key-statistics . Accessed November 2013

Note: Data in this release correspond to ASH Abstracts 1806 and 505.

U.S. Media Inquiries: Ilona RubinoPhone: 1-215-793-7227Mobile : 1-484-678-8698

EU Media Inquiries: Satu GlawePhone: 49-2638-947-9218

Investor Relations: Stan PanasewiczPhone: 1-732-524-2524

Louise MehrotraPhone: 1-732-524-6491

U.S. Medical Inquiries:1-800-526-7736

SOURCE Janssen Research & Development, LLC

Copyright 2011 PR Newswire. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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