IRVINE, Calif., Dec. 3, 2013 (GLOBE NEWSWIRE) -- MRI Interventions, Inc. (OTCQB:MRIC) today announced the presentation of clinical data demonstrating the precision of MRI-guided delivery of the investigational gene therapy Toca 511 to high grade gliomas using the company's ClearPoint ® Neuro Intervention System as the delivery platform. At the 4 th Quadrennial Meeting of the World Federation of Neuro-Oncology, held in conjunction with the 18 th Annual Society for Neuro-Oncology Scientific Meeting and Education Day, Dr. Manish Aghi, neurosurgeon at University of California, San Francisco (UCSF), presented a poster showing interim data from an ongoing Phase I clinical trial evaluating the safety and tolerability of Toca 511 in combination with Toca FC in recurrent high grade glioma patients.
- Toca 511 dose levels studied to date have been safe and well-tolerated;
- Using direct MRI guidance, delivery of Toca 511 into as many as four locations in the tumor, at flow rates of up to 30 µL/min has been achieved without reflux;
- Analysis of tumor from a patient who underwent MRI-guided delivery of Toca 511 showed Toca 511 gene expression;
- In certain patients, following treatment with Toca 511 and Toca FC, MRI changes consistent with antitumor activity have been observed.