November 22, 2013
ThromboGenics NV (Euronext Brussels: THR), an integrated biopharmaceutical company focused on developing and commercializing innovative ophthalmic medicines, announces that its Founder and Chairman Prof
has received the Scrip Lifetime Achievement award. He was presented with this prestigious industry award at the Scrip Awards 2013 event held in
The Scrip Awards, now in their ninth year, are one of the most prestigious awards recognizing excellence in the global biopharmaceutical and clinical research industries. The Scrip Lifetime Achievement Award is reserved for an individual who has made an outstanding contribution to the pharmaceutical/biotech industry.
Prof Collen, commenting on his award, said: "I am extremely honoured to have won this award. To receive this level of recognition from the industry that I have dedicated most of my life to is extremely gratifying. I am very pleased that my efforts have led to two drugs that provide important patient benefits reaching the market and the creation of a number of promising biotech companies that I hope will be successful in bringing even more novel therapies to treat areas of high unmet medical need."
Prof Collen played a key role in the development of both tissue plasminogen activator (tPA) for acute myocardial infarction and ischemic stroke, and JETREA
(ocriplasmin) for the treatment of symptomatic vitreomacular adhesion/ vitreomacular traction. tPA was a key product in Genentech's success in the late 1980s and 1990s and when introduced it revolutionized the treatment of acute myocardial infarctions. The potential of Jetrea, launched earlier this year, was reflected in the licensing deal ThromboGenics signed with Alcon (part of Novartis), in
for the commercialization of this novel medicine outside the US. This deal won the Scrip Licensing Deal of the Year in 2012.
Prof Collen is also a world renowned scientist in the field of life sciences. His research interests are in the molecular biology and pathophysiology of the cardiovascular system and translational research on drug development. He has co-authored more than 650 scientific publications, and has co-invented over 20 issued patents and patent applications. He has won several scientific awards, including the Francqui Prize (
), the Prix Louis Jeantet de Médecine (
), the Bristol-Myers-Squibb award for Cardiovascular Research (
), and the Health Prize of the Interbrew-Baillet Latour Fund (
) (jointly with P. Carmeliet).
Prof Collen is a successful biotech entrepreneur and investor. He was the Founder and CEO of ThromboGenics before becoming its Chairman in 2008. In addition, he has invested in other biotech companies including Cardio 3 Biosciences which successfully listed on Euronext Brussels and
in July of this year.
(ocriplasmin) is a truncated form of human plasmin. In the US, JETREA
is indicated for the treatment of symptomatic VMA. In
is indicated for the treatment of vitreomacular traction (VMT), including when associated with macular hole of diameter ≤ 400 microns. JETREA
is a selective proteolytic enzyme that cleaves fibronectin, laminin and collagen, three major components of the vitreoretinal interface that play an important role in vitreomacular adhesion.
has been evaluated in two multi-center, randomized, double-masked Phase III trials conducted in the U.S. and
involving 652 patients with vitreomacular adhesion. Both studies met the primary endpoint of resolution of VMA at day 28.
JETREA's Phase III program found that 26.5% of patients treated with ocriplasmin saw resolution of VMA, compared with 10.1% of patients receiving placebo (p<0.01). The Phase III program also showed that JETREA was generally well tolerated with most adverse events being transient and mild in severity.