"Advanced recurrent non-small cell lung cancer remains an area of medical need. We are pleased to initiate this trial combining vantictumab, with its novel anti-cancer stem cell mechanism of action, with standard docetaxel chemotherapy and our preclinical studies have generated robust anti-tumor activity data for this combination," said Jakob Dupont, M.D., Chief Medical Officer of OncoMed. "From this trial we will learn more about the safety, biomarker effects, and potential efficacy of this novel Wnt pathway-targeting drug candidate in combination with chemotherapy in advanced NSCLC."OncoMed recently initiated a Phase 1b study of vantictumab and paclitaxel in HER2 negative breast cancer. Interim results for the single-agent, first-in-human Phase 1a trial for vantictumab in solid tumor patients were reported at the European Cancer Congress (ECC) 2013 in Amsterdam, Netherlands in September 2013. Results from the Phase 1a study showed that vantictumab is well tolerated with early evidence of single agent activity. Additionally, clinical biomarker data from the Phase 1a trial indicating PD modulation of the Wnt pathway by vantictumab were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, MA in October 2013.
OncoMed Pharmaceuticals Initiates Second Phase 1b Clinical Trial Of First-in-Class WNT-Pathway-Targeting Antibody Vantictumab (OMP-18R5) With Docetaxel In Non-Small Cell Lung Cancer (NSCLC)
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