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Immunomedics Announces IMMU-132 Is Active In Patients Refractory To Irinotecan

NEW YORK, Nov. 8, 2013 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced that some patients who had failed prior therapy with irinotecan or camptosar, both topoisomerase-1 inhibitors, responded to IMMU-132, the Company's lead antibody-drug conjugate (ADC) in clinical development for the treatment of patients with solid cancers.

Dr. Allyson Ocean of Weill-Cornell Medical College, New York, NY, was invited by the Program Chairs to present the updated results at the Symposium, which is jointly organized by the Mount Sinai School of Medicine and the Chemotherapy Foundation, a non-profit organization supporting cancer research, in collaboration with The Tisch Cancer Institute.

An overall disease control rate of 82% in 22 computed tomography-assessable patients were reported. These include 15 patients with stable disease as their best response and 3 patients, one in each of triple-negative breast, colorectal and small-cell lung cancers, with a partial response.

For the 18 patients who responded to IMMU-132, 8 had failed prior therapies with irinotecan or camptosar. Because irinotecan is the parent of SN-38, the Company's drug of choice in IMMU-132, we postulate that the increased amount of SN-38 delivered to the tumors by IMMU-132 overcomes the tumor's resistance to this class of drugs.

"We are enthused that IMMU-132 has shown activity in a patient population with advanced, difficult-to-treat solid cancers that are refractory to multiple prior therapies including irinotecan," commented Cynthia L. Sullivan, President and Chief Executive Officer of Immunomedics. "The trial has been expanded to a Phase II and is enrolling patients rapidly. We look forward to reporting results from this proof-of-concept trial," Ms. Sullivan added.

In addition to the 25 patients enrolled into the Phase I, dose-escalation part of the study, 18 patients have now been enrolled into the expanded Phase II trial. These Phase II patients include 8 with pancreatic cancer, 7 with colorectal cancer, and one patient each with ovarian, triple-negative breast, and gastric cancers.

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