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CTI Announces Data Presentations At The 55th American Society Of Hematology Annual Meeting

SEATTLE, Nov. 7, 2013 /PRNewswire/ -- Cell Therapeutics, Inc. (CTI) (NASDAQ and MTA: CTIC) today announced the upcoming presentations of data highlighting pacritinib, a novel, oral JAK2/FLT3 inhibitor, and tosedostat, an aminopeptidase inhibitor, at the 55th American Society of Hematology (ASH) Annual Meeting and Exposition, being held December 7-10, 2013 in New Orleans, LA. 

The presentations will include data from additional analyses of completed Phase 2 trials of pacritinib in patients with myelofibrosis and data from investigator-sponsored clinical trials of tosedostat for first line acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) and a separate study in relapsed patients. A summary of the presentations is below, and full abstracts can be accessed on the ASH website at www.hematology.org.

Oral Presentation

Pacritinib, a Dual JAK2/FLT3 Inhibitor: An Integrated Efficacy and Safety Analysis of Phase II Trial Data in Patients with Primary and Secondary Myelofibrosis (MF) and Platelet Counts ≤ 100,000 µL

  • First Author:  Dr. Srdan Verstovsek, MD Anderson Cancer Center, Houston, TX
  • Date/Time:  Monday, December 9, 2013 at 11:30 a.m. CT
  • Location:  Theater C
  • Oral Session:  634, Myeloproliferative Syndromes: Clinical I
  • Abstract #395

Poster Presentations

A Phase I/II Study of Cytarabine or Azacitidine in Combination with Tosedostat in Older Patients with AML or High-Risk MDS

  • First Author: Dr. Courtney DiNardo, MD Anderson Cancer Center, Houston, TX
  • Date/Time:  Sunday, December 8, 2013, 6:30-8:30 p.m. CT
  • Location:  Hall E
  • Poster Presentation:  615, Acute Myeloid Leukemia: Therapy, excluding Transplantation: Poster II
  • Abstract #2698

A Phase II Study of Tosedostat (TST) in Combination with Either Cytarabine or Decitabine in Newly Diagnosed Older Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

  • First Author:  Dr. Raya Mawad, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA
  • Date/Time:  Monday, December 9, 2013, 6:00-8:00 p.m. CT
  • Location:  Hall E
  • Poster Presentation:  615, Acute Myeloid Leukemia: Therapy, excluding Transplantation: Poster III
  • Abstract #3926

Exposure-Response Analysis for Pacritinib (SB1518), a Novel Oral JAK2/FLT3 Inhibitor, In Patients With Myelofibrosis

  • First Author:  Dr. Suliman Al-Fayoumi, Cell Therapeutics, Inc., Seattle, WA
  • Date/Time: Monday, December 9, 2013 at 6:00-8:00 p.m. CT
  • Location:  Hall E
  • Poster Presentation: 634, Myeloproliferative Syndromes: Clinical: Poster III
  • Abstract #4080

About Pacritinib

Pacritinib is an oral tyrosine kinase inhibitor (TKI) with dual activity against JAK2 and FLT3.  The JAK family of enzymes are a central component in signal transduction pathways, which are critical to normal blood cell growth and development as well as inflammatory cytokine expression and immune responses.  Mutations in these kinases have been shown to be directly related to the development of a variety of blood related cancers including myeloproliferative neoplasms, leukemia and lymphoma.  Pacritinib may offer an advantage over other JAK inhibitors through effective treatment of symptoms while having less treatment-emergent thrombocytopenia and anemia than has been seen in currently approved and in-development JAK inhibitors.

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