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Infinity Announces Clinical And Preclincial Data To Be Presented At ASH 2013 Annual Meeting

Stocks in this article: INFI

Infinity Pharmaceuticals, Inc. (NASDAQ: INFI) today announced that new data for IPI-145, the company’s oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma, will be presented at the American Society of Hematology (ASH) 2013 Annual Meeting, which is being held December 7-10 in New Orleans, Louisiana.

Key results to be presented during the meeting include updated data from Infinity’s Phase 1 study evaluating the safety, clinical activity and pharmacokinetics of IPI-145 in patients with chronic lymphocytic leukemia (CLL). Updated topline Phase 1 data on the activity of IPI-145 in patients with indolent non-Hodgkin lymphoma (iNHL) and T-cell lymphoma will also be reported. Additionally, the company will present preclinical and/or translational data supporting the potential of IPI-145 across a range of hematologic malignancies, including iNHL, CLL, diffuse large B‐cell lymphoma (DLBCL) and T‐cell acute lymphoblastic leukemia (ALL).

Presentations of IPI-145 at ASH 2013 include the following:

Saturday, December 7, 2013, 5:30 p.m. – 7:30 p.m. CT (poster presentations)

Title: Treatment with the potent PI3K‐delta,gamma inhibitor IPI‐145 is associated with rapid decreases in specific cytokines, chemokines and matrix metalloproteinases in the serum of patients with chronic lymphocytic leukemia and indolent non‐Hodgkin lymphoma Presenter: Howard M. Stern, M.D., Ph.D., Infinity Pharmaceuticals, Cambridge, MA Location: Hall E

Title: The potent PI3K‐delta,gamma inhibitor, IPI‐145, exhibits differential activity in diffuse large B‐cell lymphoma (DLBCL) cell lines Presenter: Jeffery L. Kutok, M.D., Ph.D., Infinity Pharmaceuticals, Cambridge, MA Location: Hall G

Title: The potent PI3K‐delta,gamma inhibitor, IPI‐145, exhibits preclinical activity in murine and human T‐cell acute lymphoblastic leukemia Presenter: Xiaoyan Huang, M.D., MSc., Department of Hematopathology, MD Anderson Cancer Center, Houston, TX Location: Hall E

Sunday, December 8, 2013, 6:00 p.m. – 8:00 p.m. CT (poster presentation)

Title: Inhibition of PI3K-delta and -gamma isoforms by IPI-145 in chronic lymphocytic leukemia overcomes signals from PI3K/AKT/S6 pathway and promotes apoptosis Presenter: Kumudha Balakrishnan, Ph.D., Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX Location: Hall E

Monday, December 9, 2013, 4:30 p.m. – 6:00 p.m. CT (oral presentation at 5:30 p.m. CT)

Title: Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-delta,gamma, in patients with chronic lymphocytic leukemia Presenter: Ian W. Flinn, M.D., Sarah Cannon Research Institute, Nashville, TN Location: Room 295-296

Third Quarter Financial Results Conference Call/Webcast Reminder

As previously announced, Infinity will hold a conference call at 4:30 p.m. ET today to review its third quarter 2013 financial results, share an update on its business and provide an overview of the ASH abstracts referenced above. A live webcast of the conference call can be accessed in the Investors/Media section of Infinity's website at www.infi.com. To participate in the conference call, please dial 1-877-316-5293 (domestic) and 1-631-291-4526 (international) five minutes prior to start time. The conference ID number is 34959052. An archived version of the webcast will be available on Infinity's website for 30 days.

ASH Investor Reception and Webcast

Infinity will host a reception on Sunday, December 8, 2013, from 11:00 a.m. to 12:30 p.m. CT (12:00 p.m. to 1:30 p.m. ET) in New Orleans, Louisiana, to review its PI3K-delta,gamma program in hematologic malignancies and discuss the IPI-145 data being presented at the ASH 2013 Annual Meeting. The event will be webcast and can be accessed in the Investors/Media section of Infinity's website at www.infi.com. An archived version of the webcast will be available on Infinity's website for 30 days.

About the Development of IPI-145 for the Treatment of Blood Cancers

Infinity is developing IPI-145, an oral inhibitor of Class I PI3K-delta,gamma. The PI3Ks are a family of enzymes involved in multiple cellular functions, including cell proliferation and survival, cell differentiation, cell migration and immunity. The PI3K-delta,gamma isoforms are preferentially expressed in leukocytes (white blood cells), where they have distinct and mostly non-overlapping roles in immune cell development and function. Targeting PI3K-delta and PI3K-gamma may provide multiple opportunities to develop differentiated therapies for the treatment of hematologic malignancies as well as inflammatory diseases.

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