This study suggests a 'two hit model' for the risk for pain syndromes: an initial stressor that predisposes to increased reactivity to later stress. The authors implicate both stress response and inflammation systems in the body in the link between stress and pain, potentially pointing to new treatment mechanisms."Chronic pain is a significant problem for people with PTSD. One reason for the co-occurrence of PTSD and pain is that the events that produce PTSD also may be associated with bodily harm. We have long known that childhood stress increases the vulnerability to PTSD. This new study also raises the possibility that early life stressors may increase the risk for pain syndromes," noted John H. Krystal, M.D., Editor of Biological Psychiatry.
Hypersensitivity To Pain Produced By Early Life Stress Is Worsened By Later Stress Exposure
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