This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
$1 buys you full access to ALL of TheStreet's Subscription Services! Learn More

ImmunoGen, Inc. Reports On Additions To Its Industry-Leading ADC Technology Portfolio At AACR-NCI-EORTC Conference

Stocks in this article: IMGN

ImmunoGen, Inc. (Nasdaq: IMGN) today reported on additions to the Company’s portfolio of antibody-drug conjugate (ADC) technologies at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics meeting being held in Boston, MA. 1,2,3 Of particular interest were presentations on the Company’s new platform of DNA-acting payload agents ImmunoGen has created to further extend the opportunity for ADC cancer treatments.

New Platform of DNA-Acting Payload Agents

ImmunoGen scientists presented preclinical data on the Company’s IGN platform of DNA-acting agents, developed for use in ADCs. 1,2 These agents complement the Company’s existing, successful platform of tubulin-acting payload agents (e.g., DM1, DM4). ImmunoGen created its IGNs to expand the opportunity for ADC therapies – to enable the development of effective ADCs for cancers such as those not sensitive to tubulin-acting agents, those with low levels of antigen expression, and those with multidrug resistance.

As reported today, ImmunoGen scientists created IGN di-imines that demonstrate potent anticancer activity in preclinical testing – both alone and as the payload component of an ADC. They then identified that certain IGN modifications greatly enhance the tolerability of IGN-ADCs, without loss of potency, enabling achievement of anticancer agents demonstrating a notable therapeutic window in preclinical models.

The presentations today include data showing in vivo activity and tolerability, on both an acute and sustained basis, of ADCs utilizing such modified IGNs (IGN mono-imines). Data were reported for IGN-ADCs to different antigen targets and included activity against both hematological and solid tumors.

Also reported were data showing the marked impact of linker selection on achievement of an optimized ADC with these IGN payload agents. 2 ImmunoGen scientists have previously reported on the impact of linker selection on achievement of an optimized ADC with the Company’s tubulin-acting payload platform. 4

“Our technologies and approaches are designed to achieve effective, well-tolerated and producible ADC products,” commented John Lambert, PhD, ImmunoGen EVP and Chief Scientific Officer. “While there can be a tendency in this field to want to focus on one element of an ADC – the linker, payload or manufacturing approach – experience shows that ADCs are best thought of as integrated systems.”

1 of 2

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!

Markets

DOW 17,828.24 +0.49 0.00%
S&P 500 2,067.56 -5.27 -0.25%
NASDAQ 4,791.63 +4.3130 0.09%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs