ImmunoGen, Inc. (Nasdaq: IMGN) today reported on additions to the Company’s portfolio of antibody-drug conjugate (ADC) technologies at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics meeting being held in Boston, MA. 1,2,3 Of particular interest were presentations on the Company’s new platform of DNA-acting payload agents ImmunoGen has created to further extend the opportunity for ADC cancer treatments.
New Platform of DNA-Acting Payload Agents
ImmunoGen scientists presented preclinical data on the Company’s IGN platform of DNA-acting agents, developed for use in ADCs. 1,2 These agents complement the Company’s existing, successful platform of tubulin-acting payload agents (e.g., DM1, DM4). ImmunoGen created its IGNs to expand the opportunity for ADC therapies – to enable the development of effective ADCs for cancers such as those not sensitive to tubulin-acting agents, those with low levels of antigen expression, and those with multidrug resistance.
As reported today, ImmunoGen scientists created IGN di-imines that demonstrate potent anticancer activity in preclinical testing – both alone and as the payload component of an ADC. They then identified that certain IGN modifications greatly enhance the tolerability of IGN-ADCs, without loss of potency, enabling achievement of anticancer agents demonstrating a notable therapeutic window in preclinical models.The presentations today include data showing in vivo activity and tolerability, on both an acute and sustained basis, of ADCs utilizing such modified IGNs (IGN mono-imines). Data were reported for IGN-ADCs to different antigen targets and included activity against both hematological and solid tumors. Also reported were data showing the marked impact of linker selection on achievement of an optimized ADC with these IGN payload agents. 2 ImmunoGen scientists have previously reported on the impact of linker selection on achievement of an optimized ADC with the Company’s tubulin-acting payload platform. 4 “Our technologies and approaches are designed to achieve effective, well-tolerated and producible ADC products,” commented John Lambert, PhD, ImmunoGen EVP and Chief Scientific Officer. “While there can be a tendency in this field to want to focus on one element of an ADC – the linker, payload or manufacturing approach – experience shows that ADCs are best thought of as integrated systems.”