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OncoMed Pharmaceuticals Presents Data From Clinical Trials Of Four Novel Anti-Cancer Stem Cell (Anti-CSC) Therapeutics At The AACR-NCI-EORTC International Conference On Molecular Targets And Cancer Therapeutics In Boston, October 19-23, 2013

About Vantictumab (OMP-18R5)

Vantictumab is a first-in-class antibody that has shown broad anti-CSC and anti-tumor activity in patient-derived xenograft tumor models. Vantictumab inhibits a key signaling pathway in cancer, the Wnt pathway. Specifically, vantictumab selectively targets Frizzled receptors, which are activators of Wnt signaling. Although vantictumab was originally identified by binding to Frizzled7, the antibody selectively targets five different Frizzled receptors. Vantictumab is currently in Phase 1a. Data from this clinical trial were presented at the European Cancer Conference (ECC 2013) in September 2013 in Amsterdam, NL. Biomarker data for this Phase 1a trial were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, MA, in October 2013. Vantictumab is part of OncoMed's collaboration with Bayer Pharma AG.

About Anti-Notch1 (OMP-52M51)

Anti-Notch1 is a first-in-class antibody that has shown broad anti-CSC and anti-tumor activity in specific patient-derived xenograft tumor models. Anti-Notch1 inhibits a key signaling pathway in cancer, the Notch pathway. Specifically, anti-Notch1 selectively targets the Notch1 receptor and prevents signaling through this important Notch receptor. Certain lymphoid malignancies and solid tumors have abnormal activation of the Notch1 receptor that can be a key driver of these tumors. Anti-Notch1 is being developed with potential predictive biomarker companion diagnostics. Anti-Notch1 is currently in Phase 1 in two first-in-human trials, one in lymphoid malignancies and one in certain solid tumors. Data from the anti-Notch1 refractory solid tumor trial were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, MA, in October 2013. Anti-Notch1 is part of OncoMed's collaboration with GlaxoSmithKline.

About Fzd8-Fc (OMP-54F28)

Fzd8-Fc is a first-in-class fusion protein that has shown broad anti-CSC and anti-tumor activity in patient-derived xenograft tumor models. Fzd8-Fc inhibits a key signaling pathway in cancer, the Wnt pathway. Specifically, Fzd8-Fc consists of the extracellular ligand-binding domain of the Frizzled 8 receptor and the Fc domain of a human IgG1 antibody. Fzd8-Fc selectively binds Wnt ligands, which are activators of Wnt signaling. Fzd8-Fc is currently in Phase 1a in patients with refractory solid tumors. Data from the Fzd8-Fc solid tumor trial were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, MA, in October 2013. Fzd8-Fc is part of OncoMed's collaboration with Bayer Pharma AG.

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