SAN DIEGO, Oct. 15, 2013 (GLOBE NEWSWIRE) -- Given Imaging (Nasdaq:GIVN), a world leader in specialty GI products and pioneer of capsule endoscopy, today announced new studies validating PillCam SB's role in improving care, management and outcomes for patients with known or suspected Crohn's disease. The studies were presented at the American College of Gastroenterology's Annual Scientific Meeting and Postgraduate Course (ACG), taking place October 11-16, 2013, at the San Diego Convention Center, San Diego, CA, where Given Imaging is exhibiting at booth #1200 throughout the conference.
"PillCam SB is one of the most important tools we have for detecting and monitoring small bowel diseases, such as Crohn's disease. Due to the evolving nature of Crohn's disease, it's crucial that we monitor mucosal healing, as well as disease progression, so that we are able to continually improve the targeting of our treatment regimens," said Neel K. Mann, M.D., Associate Director, Small Bowel Enteroscopy, Cedars-Sinai Medical Center. "The compelling new data being presented at this year's ACG meeting shows that PillCam SB can help us reclassify disease phenotype to create a more tailored and effective management plan for each patient."
Several ACG poster presentations highlighted the clinical benefit of PillCam SB in Crohn's patients as a safe and valuable tool in disease evaluation and management, including:
- "Capsule Endoscopy (CE) Can Improve Outcomes in Crohn's Disease: An Evaluation of Pre- and Post-treatment CE," poster 426, presented by Neel K. Mann, M.D. and Simon K. Lo, M.D., Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, Calif. The aim of this retrospective study was to assess small bowel mucosal healing based on the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI, Dig Dis Sci (2008) 53:1933-27) after initiation or escalation of therapy. CE results led to an escalation of therapy or switching of biologic agents in 53.6% of patients. There was a statistically significant difference in the CECDAI between the pre- and post-treatment CE (p=0.0250.) The study's authors concluded that PillCam SB helped to re-classify disease phenotype in more than 60% of patients with suspected Crohn's disease or unclassified Inflammatory Bowel Disease, thereby potentially changing the management as well as the natural outcomes of small bowel Crohn's disease. More importantly, capsule endoscopy demonstrated mucosal healing in 70% patients, after assessment of therapy, positively changing disease outcome and achieving therapeutic goals in patients with non-stricturing phenotype Crohn's disease.
- "Clinical Impact of Capsule Endoscopy in Patients with Established Crohn's Disease," poster 1720 , presented by researchers at McGill University Health Center, Montreal, QC, Canada, examined the impact of PillCam SB on the management of patients with established Crohn's disease. The results of this retrospective cross-sectional study of patients with established Crohn's disease showed that as a result of PillCam SB findings, 67% of patients had a change in management, including escalation in therapy, referral for surgery, de-escalation of anti-inflammatory therapy or initiation of therapy for concomitant IBS. Investigators concluded that PillCam SB, a safe and valuable tool in disease evaluation and management, had a significant impact on managing treatment options for patients with established Crohn's disease.
- To help assess the value of monitoring in therapeutic management for Crohn's disease, Given Imaging supported researchers from the University of Chicago, Chicago Ill. and Cedars Sinai Medical Center, Los Angeles, Calf. in a national survey of gastroenterologists. An analysis of this survey was presented by Adam C. Stein, M.D. in poster 420 , "Mucosal Healing in Inflammatory Bowel Disease: A Nationwide Survey of Gastroenterologists' Current Practice Patterns" . The survey was conducted among community and academic gastroenterologists to determine current practice patterns for both achieving and maintaining mucosal healing in Crohn's and Ulcerative Colitis. Results showed that the majority of surveyed gastroenterologists agreed that mucosal healing is the primary management goal in patients with both Crohn's and Ulcerative Colitis, and 57.1% indicated they would perform periodic endoscopy for disease monitoring even after mucosal healing was achieved and the patient was asymptomatic, or to assess for post-operative recurrence in Crohn's disease after ileocectomy with primary anastomosis.