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BETHESDA, Md., Oct. 11, 2013 (GLOBE NEWSWIRE) -- Sucampo Pharmaceuticals, Inc. (Nasdaq:SCMP) ("Sucampo") today announced the presentation of three posters evaluating AMITIZA® (lubiprostone) in opioid-induced constipation (OIC). Two posters will be presented at the American College of Gastroenterology (ACG) Annual Scientific Meeting in San Diego, California on October 13 and 15, 2013, and the third poster will be presented at the American College of Clinical Pharmacy (ACCP) Annual Meeting in Albuquerque, New Mexico on Wednesday, October 16, 2013.
AMITIZA is the world's first chloride channel activator that increases intestinal fluid secretion, softens stools, and increases intraluminal fluid volume to initiate colonic transit and improve bowel function independent of motility, thereby facilitating the passage of stool and alleviating symptoms associated with chronic constipation. AMITIZA, via activation of apical ClC-2 channels in the intestinal epithelium, bypasses the antisecretory action of opiates.
The first poster listed below will be presented by Dr. Byron Cryer, lead author and Professor of Medicine, University of Texas Southwestern Medical Center, from 3:30 to 7:00 PM PT on Sunday, October 13, 2013. The second poster will be presented by Dr. Shadreck Mareya, Sucampo's Director of Clinical Program Management, on Tuesday, October 15, 2013 from 10:30 AM to 4:00 PM PT:
Spontaneous Bowel Movement Frequency Is Improved Over 12 Weeks of Lubiprostone Therapy in Opioid-Induced Constipation Patients Regardless of Gender, Age, or Race: Pooled Analysis of Three Well-Controlled Studies (Byron Cryer, MD, FACG, Shadreck Mareya, PhD, Taryn Joswick, BS, PMP, Gayle Dolecek, PD, MPH, Yijun Sun, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 493
Lubiprostone Effectively Relieves Opioid-Induced Constipation in Patients Using Non-Diphenylheptane Opioids for Non-Cancer Pain: Pooled Analysis of 3 Randomized Controlled Trials (Shadreck Mareya, PhD, Douglas A. Drossman, MD, MACG, Taryn Joswick, BS, PMP, Gayle Dolecek, PD, MPH, Yijun Sun, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 1687
The following poster will be presented by Taryn Joswick, Sucampo's Vice President of Clinical Development, during the Poster Session at ACCP on Wednesday, October 16, 2013, between 8:00 AM to 10:00 AM MT:
Lubiprostone for Treatment of Opioid-Induced Constipation Does Not Interfere With Opioid Analgesic Effects in Patients With Non-Cancer Pain (Egilius L. H. Spierings, MD, PhD, Taryn Joswick, BS, PMP, Shadreck Mareya, PhD, Yijun Sun, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 137
Lubiprostone is available under the brand name AMITIZA® in the U.S. AMITIZA capsules are indicated for the treatment of chronic idiopathic constipation (CIC) in adults and opioid induced constipation (OIC) in adults with chronic, non-cancer pain (24 mcg twice daily). The effectiveness in patients with OIC taking diphenylheptane opioids (e.g., methadone) has not been established. AMITIZA is also indicated for irritable bowel syndrome with constipation (IBS-C) in women > 18 years old (8 mcg twice daily).