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Cytori Therapeutics (NASDAQ:CYTX) has received an Australian patent covering methods of treating cardiovascular disease using adipose-derived regenerative cells (ADRCs). The patent covers the therapeutic use of ADRCs for improving cardiac function and mechanics by preventing the deleterious histopathological and structural changes that occur in the heart following a heart attack (cardiac remodeling).
“This patent expands our growing body of global patents surrounding therapeutic uses for our Celution® cell output,” said Christopher Calhoun, CEO of Cytori. “As previously reported, we are encouraged by the positive clinical results in our cardiovascular trials to date and cardiovascular disease remains a core focus of the Company.”
The patent is not limited to any particular way of obtaining ADRCs, covering both manual and automated methods of obtaining the cells. This includes the use of a sterile, closed system such as Cytori’s proprietary Celution® System. The claims also cover multiple cell populations and cell delivery methods, including intravenous delivery.
Cytori received notice from the Australian Therapeutic Goods Administration (TGA) that the Celution® System was approved for commercial use through inclusion on the Australian Registry of Therapeutic Goods for autologous re-implantation and re-infusion of a patient’s own ADRCs in August 2013. This approval enables physicians to treat critical unmet medical needs with point-of-care cell therapies and to conduct important clinical research in promising therapeutic areas.
The patent complements Cytori’s existing patents in Australia covering the Celution® System and builds upon the Company's global patent strategy encompassing therapeutic indication-specific, methods and device patents. Cytori now has 64 issued patents and more than 75 active patent applications worldwide.
About Adipose Tissue & ADRCs
Adipose tissue is considered the richest source of regenerative cells in the body. These cells are comprised of a heterogeneous population of cells which are collectively referred to as ADRCs. The heterogeneous nature of ADRCs are believed to contribute to the healing process via multiple mechanisms, which include cell-to-cell signaling, supporting improved blood flow and regulation of the inflammatory response.