EGFR is frequently hyperactive in a number of cancers, including lung cancer, anal cancers and glioblastoma. Drugs such as Iressa (gefitinib) and Tarceva (erlotinib) directly target EGFR, but are only found to be effective in the absence of certain mutations that can be identified using the EGFR MASTR kit.In approximately 80% of GISTs, mutations in the cKIT gene contribute to the growth of the tumor cells. Among tumors that lack a cKIT mutation, some have mutations in a closely related gene called PDGFRA (about 5-7% of all GISTs). Knowledge of the exact type and location of a mutation in the KIT or PDGFRA gene, using the GIST MASTR kit, can be used to predict the likelihood that the tumor will respond to treatment with Gleevec (imatinib).
Multiplicom Launches Three New Mutation Detection Kits To Enable The Implementation Of Personalized Cancer Treatment
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