This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Exelixis Announces Presentation Of Updated Phase 1b Data For Cobimetinib (GDC-0973/XL518) In Combination With Vemurafenib At ECC 2013

Stocks in this article: EXEL


The most common adverse events (AEs) regardless of attribution to study treatment in the 128 patients treated to date were: non-acneiform rash (35% [2% ≥ Grade 3] for vemurafenib-progressors; and 89% [13% ≥ Grade 3] for BRAFi-naïve), diarrhea (48% [3%]; 81% [8%]), photosensitivity/sunburn (48% [3%]; 70% [0%])), fatigue (28% [2%]; 67% [10%]), nausea (32% [3%]; 56% [3%]), arthralgia (11% [2%]; 48% [11%]), CPK elevation (15% [2%]; 43% [3%]), fever (14% [0%]; 43% [2%]), peripheral edema (20% [0%]; 41% [0%]), vomiting (19% [2%]; 37% [0%]), and acneiform rash (12% [2%]; 33% [3%]). Selected AEs were: choreoretinopathy (2% [0]; 9% [0%]), cardiomyopathy [0% [0%]; 2% [2%]), and squamous cell carcinoma/keratocanthoma (8% [6%]; 10% [5%]).

Temporary interruptions in vemurafenib, cobimetinib, or the combination of both agents were reported in 20%, 20%, and 19% of the 65 vemurafenib-progressor patients, respectively. Dose reductions were reported in 5% 3%, and 3% of vemurafenib-progressor patients, respectively, and permanent discontinuation was reported for vemurafenib (3%) only. Among the 63 BRAFi-naïve patients, temporary interruptions in vemurafenib, cobimetinib, or the combination of both agents were reported in 67%, 49%, and 46%, and dose reductions were reported in 19%, 16% and 2% of patients, respectively. Permanent discontinuation of cobimetinib was reported for one BRAFi-naïve patient (2%). None of the 128 patients receiving the combination of vemurafenib and cobimetinib discontinued treatment due to an adverse event to date.

About Cobimetinib (GDC-0973/XL518)

Cobimetinib is an inhibitor of MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway. This pathway mediates signaling downstream of growth factor receptors, and is prominently activated in a wide variety of human tumors. In preclinical studies, oral dosing of cobimetinib resulted in sustained inhibition of MEK in RAS or BRAF mutant tumor models. Cobimetinib is being developed by Genentech, a member of the Roche Group under a collaboration agreement with Exelixis.

3 of 5

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 18,030.21 +6.04 0.03%
S&P 500 2,081.88 -0.29 -0.01%
NASDAQ 4,773.4720 +8.0480 0.17%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs