Sept. 4, 2013
/PRNewswire/ -- Abbott (NYSE: ABT) announced today promising preliminary results from a study presented at the ESC Congress 2013, suggesting that its high sensitive troponin test may help doctors improve the diagnosis and prognosis of patients presenting with symptoms of a heart attack. The test could be particularly beneficial for women, who may have different presenting symptoms and are often under-diagnosed. The study, which is being conducted by researchers at the
University of Edinburgh
, is evaluating Abbott's ARCHITECT
High Sensitive Troponin-I (hsTnI) test, which received CE Mark in
Cardiac troponin, a protein found in the heart muscle, is considered the preferred biomarker to identify suspected heart attacks, because it can detect injury to the heart. Abbott's hsTnI test can measure very low levels of this protein, which is especially important for women, who often have lower levels of troponin than men.
Researchers shared data from the first 1,126 patients of the study presenting with symptoms of a heart attack. Early findings demonstrate that women have lower peak levels of troponin than men, contributing to the under-diagnosis and therefore under-treatment of heart attacks for women.
"Whilst men and women are just as likely to present to the emergency department with chest pain, currently men are twice as likely to be diagnosed with a heart attack. By using the Abbott high sensitive troponin test and different diagnostic thresholds for men and women, the frequency of diagnosis of heart attacks in women increased and was comparable to men," said Dr.
, one of the key study authors and cardiologist,
University of Edinburgh
. "The findings of our study, when completed, could change the way we diagnose heart attacks in women, potentially reducing inequalities in the treatment and outcomes, and enabling everyone to receive the best care."
When completed in 2016, this study will include more than 25,000 patients across 10 centers in
, making it one of the largest studies to evaluate the impact of high sensitive troponin tests on patient care. The study was funded by a special project grant from the British Heart Foundation with Abbott providing the ARCHITECT
"While Abbott's high sensitive troponin test benefits both men and women with earlier detection of heart attacks, the potential to increase the diagnosis among women is especially important," said
, PhD, divisional vice president, Diagnostics Research, Abbott. "This is the first time we have seen a test that can provide this kind of detailed information to doctors and has the potential to aid doctors with improving the odds of survival for women with heart attacks."
hsTnI assay is commercially available in several countries in
, as well as
and runs on Abbott's fully automated ARCHITECT family of analyzers. The test is currently for research-use only in
the United States
Women and Cardiovascular Disease
The most common heart attack symptoms in women is some type of pain, pressure or discomfort in the chest., Out of the 16.5 million cardiovascular deaths that occur globally each year, half are among women. In fact, heart attacks and strokes are responsible for twice as many deaths in women as all cancers combined. One study shows that women younger than 55 who had a heart attack were more likely to be misdiagnosed than men of the same age.
To learn more about women and cardiovascular disease, please visit
How Women Can Beat the Odds
About Abbott Diagnostics
Abbott is a global leader in
diagnostics and offers a broad range of innovative instrument systems and tests for hospitals, reference labs, molecular labs, blood banks, physician offices and clinics. With more than 22,000 customers in more than 100 countries, Abbott's diagnostic products offer customers automation, convenience, bedside testing, cost effectiveness, and flexibility. Abbott has helped transform the practice of medical diagnosis from an art to a science through the company's commitment to improving patient care and lowering costs.
Abbott is a global healthcare company devoted to improving life through the development of products and technologies that span the breadth of healthcare. With a portfolio of leading, science-based offerings in diagnostics, medical devices, nutritionals and branded generic pharmaceuticals, Abbott serves people in more than 150 countries and employs approximately 70,000 people.
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 Anoop S, Mills, N, Griffiths M, et. al. High-sensitivity cardiac troponin and the underdiagnosis of myocardial infarction in women. Study presented at the ESC Congress 2013,
September 4, 2013
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. WHO publishes results of largest-ever global collaboration on heart disease. World Health Organization press release.