) -- An experimental heart failure drug from
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failed to significantly improve shortness of breath in hospitalized patients, according to results from a mid-stage study announced Tuesday.
But heart failure patients treated with the highest dose of the drug, known as omecamtiv mecarbil, were able to breathe easier and showed sufficient, additional clinical improvements for Amgen and Cytokinetics to call the overall study outcome "encouraging."
The companies are waiting for results from a second mid-stage study of omecamtiv mecarbil expected early next year before deciding whether to invest considerable time and money to conduct phase III studies in heart failure patients.
Cytokinetics shares are down 25 percent to $7.84 in early Tuesday trading. Amgen shares are up 1% to $111.04.
The current mid-stage study, known as ATOMIC-AHF, enrolled 613 patients hospitalized with acute heart failure -- a serious and life-threatening condition in which the weakened muscles of the heart are unable to pump blood properly. Patients in the study were randomized to one of three doses of omecamtiv mecarbil given intravenously or a matching placebo injection over 48 hours.
Episodes of dypsnea, or shortness of breath, often force heart failure patients to be admitted to the hospital, so the main goal of the ATOMIC-AHF study was to determine if omecamtiv mecarbil could improve dypsnea response compared to placebo.
The dyspnea response rates were 42 percent, 47 percent and 51 percent in the low, middle and high dose omecamtiv mecarbil patient groups, compared to 41 percent in the pooled placebo group. The difference, while favoring omecamtiv mecarbil, was not statistically significant, so the primary endpoint of the study was not met.
The negative result, while disappointing, was not surprising necessarily. Amgen and Cytokinetics had been warning investors not to expect a statistically significant improvement in overall dypsnea response because the lowest dose of omecamtiv mecarbil tested was thought to be sub-therapeutic. Instead, the companies hoped to show improvements in dyspnea response that correlated with higher blood levels of omecamtiv mecarbil.
Improvement in dypsnea was reported at the highest omecamtiv mecarbil dose compared to its paired placebo -- 51 percent vs. 37 percent. Amgen and Cytokinetics said this difference was statistically significant.
An improvement in dypsnea will not be enough to get omecamtiv mecarbil approved in the U.S. or Europe. For approval, the drug will need to improve survival or significantly lower hospital re-admission rates in heart failure patients. Amgen and Cytokinetics incorporated some of these clinical endpoints in the ATOMIC-AHF study but with mixed-to-disappointing results.
The incidence of worsening heart failure within seven days of initiating treatment was 17 percent in the pooled placebo group compared to 13 percent, 8 percent and 9 percent in the low, middle and high doses of omecamtiv mecarbil, respectively. The difference, while trending favorably in the drug's direction, was not statistically significant.
There was almost no change in the median length of hospital stay for patients in the study. Placebo patients were hospitalized for a median of eight days, the same as patients treated with the highest dose of omecamtiv mecarbil. Patients treated with the low and middle dose of the drug were in the hospital for a median of eight and seven days, respectively.
Days alive out of hospital through day 30 in the pooled placebo group was 22 days, compared with 23 days for the low and middle doses of omecamtiv mecarbil and 22 days for the high dose.
Eighteen patients died during the study -- 10 treated with placebo and eight treated with omecamtiv mecarbil. (One death in the low dose, four in the middle dose and three in the high dose.)