Updated from 8:28 a.m. ET with information on casualties.
The pilot and the co-pilot, the only two occupants of the aircraft, were both killed in the carsh, Birmingham Mayor William Bell said, according to Reuters. The two have not been identified. Bell said no bystanders were hurt in the incident.
The Federal Aviation Administration said the airplane was an Airbus A300, MyFoxAL.com reported. An airport spokesman said the crash site is outside the airport's perimeter fence and has not impacted airport operation, the station said.The crash caused at least two explosions, according to NBC News affiliate WVTM. Flight 1354 was en route from the UPS hub in Louisville, Ky., a UPS spokeswoman told Bloomberg. The overnight cargo company said it is still determining details of the accident. Follow @tedreednc -- Written by Ted Reed in Charlotte, N.C. >To contact the writer of this article, click here: Ted Reed