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Genentech’s Obinutuzumab (GA101) Delayed Disease Progression Longer Than Rituxan® In People With One Of The Most Common Forms Of Blood Cancer

Stocks in this article: ROG

About the German CLL Study Group (GCLLSG)

Founded in 1996 and headed by Dr. Michael Hallek, the GCLLSG has been running various Phase III, Phase II and Phase I trials in CLL with the goal to provide optimal treatment to patients suffering from this disease. Among those were landmark trials like the CLL8 trial which led to the current standard of care in CLL. For many years, GCLLSG has been aiming to improve not just the treatment of younger and physically fit patients, but also that of elderly and less fit patients. These patients are generally underrepresented in clinical trials although they constitute the majority of CLL patients treated by doctors in daily practice. The GCLLSG is an independent non-profit research organization supported by the German Cancer Aid (Deutsche Krebshilfe).

About FDA Breakthrough Therapy Designation and Priority Review

FDA ‘Breakthrough Therapy Designation’ is designed to expedite the development and review of medicines intended to treat serious and life threatening diseases and to help ensure people have access to them through FDA approval with a shorter review time. A priority review designation is granted to medicines that the FDA believes have the potential to provide significant improvements in the treatment, prevention or diagnosis of a disease.

About Genentech in Hematology

For more than 20 years, Genentech has been developing medicines that redefine treatment in hematology. Today, we’re investing more than ever in our effort to bring innovative treatment options to people with cancers of the blood.

In addition to GA101, Genentech’s pipeline of potential hematology medicines includes two antibody-drug conjugates (anti-CD79b [RG7596] and anti-CD22 [RG7593]), a small molecule antagonist of MDM2 (RG7112) and in collaboration with AbbVie, a small molecule BCL-2 inhibitor (RG7601/GDC-0199).

About Rituxan

Rituxan is a therapeutic antibody that binds to a specific protein called CD20 found on the surface of cancerous and normal B-cells. In CLL, NHL and rheumatoid arthritis (RA), Rituxan works with the body's own immune system to eliminate marked CD20-positive B-cells. Stem cells (those cells that give rise to B-cells) in bone marrow do not have the CD20 protein. B-cells usually regenerate after Rituxan treatment and return to normal levels in about 12 months for most patients.

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