This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Synta Announces Publication Of Clinical And Non-Clinical Results Demonstrating Unique Anti-angiogenic Effects Of Ganetespib

Stocks in this article: SNTA

Synta Pharmaceuticals Corp. (NASDAQ: SNTA) announced today publication of results from in vitro, in vivo, and translational clinical studies demonstrating the effect of ganetespib on the ability of tumors to grow new blood vessels (angiogenesis). The paper appeared in the July 10, 2013, online issue of Angiogenesis. Ganetespib, a selective inhibitor of the Hsp90 chaperone protein in development by Synta, is being evaluated in over 20 clinical trials for different types of cancer, including a pivotal Phase 3 trial in non-small cell lung cancer.

“To date two therapeutic strategies have been established for inhibiting new tumor blood vessel formation: agents that bind directly to vasculature growth factors (e.g., VEGF), or agents that bind to their cellular receptors (e.g., VEGFR),” said Dr. Bassel El-Rayes, Director of the GI Oncology Translational Research Program, Winship Cancer Institute, Emory University and senior author of the paper. “The results published this week show that ganetespib may offer a third way to suppress angiogenesis: inhibiting the transcription factors that turn on production of VEGF and other pro-angiogenic factors. This is like turning off the faucet at the source, rather than trying to empty the sink once it is full.”

The publication describes results from preclinical studies and a rectal cancer clinical trial conducted at Emory University showing that ganetespib simultaneously downregulates the expression of many cellular proteins involved in new blood vessel formation, including VEGF, PDGFA, FGF2, Ang-1, Ang-2, TGFb1, HIF-1a, and STAT-3.

“Targeting angiogenesis with anti-VEGF therapies has demonstrated meaningful clinical benefit, but has also been associated with greater disease aggressiveness and metastasis from increased expression of VEGF-A and activation of HIF-1a in the hypoxic tumor,” said Dr. El-Rayes. “These studies show that the unique mechanism of action of ganetespib may provide a means to downregulate angiogenesis without upregulating HIF-1a activation and VEGF expression. These effects strongly support the rationale to combine ganetespib with standard anti-angiogenic agents.”

1 of 3

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 18,053.71 +23.50 0.13%
S&P 500 2,088.77 +6.89 0.33%
NASDAQ 4,806.8590 +33.3870 0.70%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs