Rexahn Pharmaceuticals, Inc. (NYSE MKT: RNN), a clinical stage biopharmaceutical company developing potential best-in-class oncology therapies, today announced that the Japan Patent Office has granted Patent No. 5270564 covering a series of novel isoquinolinamine compounds, their pharmaceutical composition, and method for producing an anti-tumor effect.
The patent includes inhibitors of the kinase activity of Aurora A, a family of mitotic serine/threonine kinases. Aurora A kinase has been shown to be over-expressed in many human cancer tumors including breast, colon, leukemia, lung, head and neck, ovarian and prostate. In preclinical studies, Rexahn's lead compound has shown anti-tumor activity against human cancer cell lines that do not respond well to paclitaxel, gemcitabine and cisplatin.
“The granting of this patent further strengthens Rexahn’s intellectual property position in this exciting area. The preclinical activity of the compound suggests its potential utility to treat multiple forms of cancer including breast, colon, leukemia, lung, head and neck, ovarian and prostate.” commented Peter D. Suzdak, CEO of Rexahn.
Rexahn has been awarded patents for the isoquinolinamine compounds in the United States, Europe, Australia, China, Mexico, and now Japan.
About Rexahn Pharmaceuticals, Inc.
Rexahn Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to developing best-in-class therapeutics for the treatment of cancer. Rexahn currently has three clinical stage oncology candidates, Archexin
, RX-3117, and RX-5902 and a robust pipeline of preclinical compounds to treat multiple types of cancer. Rexahn has also developed proprietary drug discovery platform technologies in the areas of nano-medicines, 3D-GOLD, and TIMES. For more information, please visit
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