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Life Technologies Ion AmpliSeq™ Exome Kit Delivers Industry's Best Performance And Simplest, Fastest Workflow*

CARLSBAD, Calif., July 2, 2013 /PRNewswire/ --  Life Technologies Corporation (NASDAQ: LIFE) today announced that its new Ion AmpliSeq™ Exome Kit delivers the best exome sequencing performance in the industry*, with up to 98 percent of bases covered at 10x, and up to 96 percent of bases covered at 20x, for a single exome.

The Ion AmpliSeq™ Exome Kit enables researchers to sequence single exomes, pairs or trios in a one sequencing run, going from DNA to data in just two days—no need to batch samples and wait weeks for results just to make sequencing affordable. The Ion Proton™ Sequencer and Ion PI™ Chip sequence up to 24 exomes in a week, and the upcoming Ion PII™ Chip is expected to sequence up to 96 exomes in a week, twenty times more than any other benchtop sequencer. The Ion Proton™ sequencer is about 1/5 the cost of the competitor's high-throughput sequencer. Additionally, introductory per-exome pricing for the complete Ion AmpliSeq™ exome workflow is lower than any other sequencing technology on the market.

The Ion AmpliSeq™ Exome Kit focuses on the exonic regions of the genome that code for proteins. About 85 percent of the genetic variants that drive human disease come from these regions, yet they account for just 1 percent of the genome, making it an ideal approach for human disease research. Exome sequencing generates 100x fewer variants than whole genome sequencing, yielding a more focused and actionable set of variants for follow up.

Exome sequencing is also significantly more affordable than sequencing whole human genomes, and the data are far easier to interpret. Despite these advantages, exome sequencing hasn't been widely adopted because most labs can't afford large next-generation sequencing systems—which cost up to $1 million—and don't have the bioinformatics experts to interpret exome data.

"The Ion AmpliSeq™ Exome Kit with the Ion Proton™ System and the upcoming Ion Chef™ System for automated template and chip loading, provide an exome solution that is superior on nearly every metric for lab scientists, core lab directors and large genome centers," said Ion Torrent President and COO Gregg Fergus. "More importantly, we are still scaling and improving at an incredible pace each and every quarter."

Simplest, fastest sample preparation workflow available today The Ion AmpliSeq™ Exome Kit delivers the simplest and fastest sample preparation workflow for exomes available today based on head-to-head comparisons with competing technology.*

With a workflow requiring less than 60 minutes of hands-on time, the Ion AmpliSeq™ Exome Kit enables exome enrichment and library construction in less than six hours and requires as little as 50 ng of input DNA. Alternatives require up to five hours of hands-on time and up to three days for enrichment and library construction.

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