- the efficacy of suvorexant has been established at doses of 10 mg to 40 mg in elderly and non-elderly adult patients;
- 10 mg should be the starting dose for most patients, and must be available before suvorexant can be approved;
- 15 mg and 20 mg doses would be appropriate in patients in whom the 10 mg dose is well-tolerated but not effective; and,
- for patients taking concomitant moderate CYP3A4 inhibitors, a 5 mg dose would be necessary.
Merck Receives Complete Response Letter For Suvorexant, Merck’s Investigational Medicine For Insomnia
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