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Ligand Announces Positive Preclinical Data For Glucagon Program In Model Of Type 1 Diabetes

Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced the presentation of a poster titled “Glucagon Receptor Antagonist LGD-6972 Is Efficacious in Streptozotocin-Induced Diabetic Mice” at the 73 rd Scientific Sessions of the American Diabetes Association in Chicago. The poster provides data from preclinical studies of Ligand’s novel compound, LGD-6972, demonstrating significant glucose lowering activity in an animal model of type 1 diabetes.

Highlights of the presentation include:

  • LGD-6972 is a potent and selective antagonist of the glucagon receptor (GCGR) that has previously demonstrated activity in pre-clinical models of type 2 diabetes.
  • LGD-6972 significantly lowered fasting and non-fasting glucose levels in a mouse model of type 1 diabetes.
  • LGD-6972 reduced HbA1c, ketone bodies, and free fatty acids in diabetic mice.
  • LGD-6972 had additive effects when used in combination with insulin therapy and may be useful in an insulin sparing regimen.

“Glucagon receptor antagonism could play an important role in the treatment of diabetes. Previous studies have demonstrated efficacy in models of type 2 diabetes and the present work shows utility for type 1 diabetes as well,” commented Matthew W. Foehr, Executive Vice President and Chief Operating Officer of Ligand. “Our glucagon program is an important example of the diversity of partnered and unpartnered products making up Ligand’s extensive portfolio of assets. We plan to submit an IND for LGD-6972 in the second half of 2013.”

About Ligand’s Glucagon Receptor Antagonist Program

Glucagon is a hormone produced by the pancreas that stimulates the liver to produce glucose (sugar). Overproduction of glucose by the liver is an important cause of high glucose levels in patients with type 2 diabetes and is believed to be due in part to inappropriately elevated levels of glucagon. High glucose levels can cause diabetic complications such as blindness and kidney disease. Glucagon receptor antagonists are designed to lower glucose levels by reducing the production of glucose by the liver. Glucagon receptor antagonists are novel molecules that have demonstrated a reduction of glucose and hemoglobin A1c in mid-stage clinical trials.

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