Amarantus BioScience Holdings, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, today announced that it plans to evaluate its LymPro Test® as a potential diagnostic and prognostic for Chronic Traumatic Encephalopathy (CTE).
“The scientific basis of cell-cycle dysfunction that underpins the rationale for development of the LymPro Test as a diagnostic blood test for Alzheimer’s disease may also be utilized to diagnose CTE in populations that have been subjected to multiple head injuries and possibly even identify individuals who are pre-disposed to developing CTE before they engage in activities likely to subject them to multiple head injuries,” said Dr. John W. Commissiong, Chief Scientific Officer of Amarantus. “As a blood test, LymPro would have significant advantages over other more complex and expensive diagnostic alternatives, in particular the ability to detect the onset of CTE at an early stage. We plan to begin the evaluation process in the second half of 2013 by conducting a small proof-of-concept clinical study in addition to our planned Alzheimer’s studies.”
Amarantus is a co-host of the Concussion Awareness Summit (#C4CT Summit) being held today at the Minneapolis Club in Minnesota, bringing together current and former professional athletes, scientists, physicians and business leaders to discuss the effects of concussions, including CTE. Dr. Commissiong will be presenting the scientific rationale for the Company’s planned studies at the #C4CT Summit later today.
The potential market for a CTE diagnostic/prognostic is large and widespread. According to various surveys and studies, approximately 1.5 1 million Americans participate in contact sports at the collegiate and high school level, with another 3.5 2 million in youth sports leagues. It is estimated that at least 1.6 3 million athletes suffer a concussion each year in the United States; 1.7 million more Americans receive traumatic brain injury through accidents every year 4; and 274,000 members of the U.S. armed forces have suffered traumatic brain injury since 2000 5.About Chronic Traumatic Encephalopathy Chronic Traumatic Encephalopathy is a progressive degenerative disease of the brain found in athletes and others with a history of repetitive brain trauma. This trauma, which includes multiple concussions, triggers progressive degeneration of the brain tissue, including the build-up of an abnormal protein called tau. These changes in the brain can begin months, years or even decades after the last concussion or end of active athletic involvement. The brain degeneration is associated with memory loss, confusion, impaired judgment, paranoia, impulse control problems, aggression, depression and, eventually, progressive dementia.