NATICK, Mass., June 18, 2013 /PRNewswire/ -- Patients with Parkinson's disease using the Boston Scientific Corporation (NYSE: BSX) Vercise™ DBS (deep brain stimulation) System showed a significant improvement in motor scores according to interim data from the VANTAGE DBS study. Data from the six month follow-up of up to 40 participants enrolled in the VANTAGE trial were presented at the annual International Congress of Parkinson's Disease and Movement Disorders in Sydney, Australia by Prof. Dr. Lars Timmermann, of University Hospital in Koln, Germany.
The Vercise DBS System incorporates multiple independent current control, which is designed to selectively stimulate targeted areas in the brain, providing physicians with fine control of stimulation.
Preliminary analysis of the VANTAGE study displays approximately 60 percent mean improvement in motor function at six months post implant, as assessed by UPDRS III 1 when compared to baseline. The Boston Scientific sponsored study was designed to document patient outcomes. These include effectiveness, safety, and health economic data derived from bilateral stimulation of the subthalamic nucleus (STN) in the brain using the implantable Vercise DBS System for the treatment of levodopa-responsive, moderate to severe idiopathic Parkinson's disease. Forty participants with Parkinson's disease were implanted bilaterally at six European centers.
"We are pleased to see such a significant improvement in motor function," said Prof. Dr. Francois Alesch, professor for Stereotactic and Functional Neurosurgery at Medical University, Vienna, Austria and neurosurgical principal investigator of the trial. "I believe this unique technology, with its multiple current sources, may provide us with a more adaptable form of DBS therapy. I was very pleased with the simple recharging system. All of my patients were able to recharge successfully."Highlights of the VANTAGE study interim data include:
- All 40 participants underwent successful implantation of the Vercise DBS System.
- The Vercise DBS System demonstrated a significant improvement in motor function (p<0.0001), as assessed by UPDRS III 1 (approximately 60 percent mean improvement) at six (6) months post first lead implant as compared with baseline.
- Preliminary analysis suggests the Vercise DBS System improved participants' ON time, as assessed by at-home motor diaries, activities of daily living 2 and quality of life 3 at six months.
- The charging of the Vercise DBS System was well tolerated by all participants.