This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Immunomedics Develops Novel Dual System For Tumor Detection And Imaging

-- Pretargeting System Allows Dual Nuclear/Fluorescence Imaging During Cancer Surgery --

-- Results Reported at SNMMI 2013 Annual Meeting --

VANCOUVER, British Columbia, June 10, 2013 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced the development of a pretargeting system that can detect and optically image a tumor during surgery. Results from this preclinical study were presented by Dr. Mark Rijpkema of the Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

While tumor detection with specific radiotracers may be a useful tool for accurate localization and resection during surgery, these procedures could benefit from the addition of an optical tracer, since this may allow for more accurate delineation of the tumor and resection margins. Both tracers in such a dual modality approach need to show high specificity and a high tumor-to-background ratio (TBR).

The pretargeting system that the Company is pursuing involves the bispecific antibody, TF2, which targets the carcinoembryonic antigen (CEA), specifically CEACAM5, expressed in many human cancers, including breast, colorectal and lung cancer, and which is also being used in its IMMU-130 antibody-drug conjugate in clinical trials. Created by the Company's proprietary DOCK-AND-LOCKā„¢ method, the bispecific antibody is currently in a number of clinical trials for pretargeted immunoPET imaging and radioimmunotherapy of patients with CEA-expressing cancers.

The other component of the pretargeting system is a small peptide bearing both the fluorescent dye, IRdye800CW, and a linker called DOTA for radiolabeling. Designated as RDC-018, this new peptide was derived from an earlier peptide, IMP288, that has been used successfully in pretargeting with a number of radioisotopes such as indium-111 ( 111In), yttrium-90, lutetium-177 and iodine-124.

The goal of this preclinical study was to assess the potential utility of this peptide for cancer detection by both optical (light) and radionuclide imaging, starting with an assessment of the radiolabeling procedure for RDC-018, and leading into in vivo biodistribution and tumor localization properties in a pretargeting setting compared to the 111In-IMP288. Animals bearing subcutaneous CEA-positive human colonic tumors and CEA-negative human renal cell tumors were used.

Biodistribution study of the RDC-018 peptide showed specific CEA-expressing tumor targeting with clearance via the kidneys similar to IMP288. Despite differences in renal uptake, RDC-018, with its ability to be imaged by both scintigraphic and optical methods, provided high tumor targeting and excellent TBR, illustrating the feasibility of this dual modality imaging approach.

1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
AAPL $93.99 0.00%
FB $102.01 0.00%
GOOG $682.40 0.00%
TSLA $151.04 0.00%
YHOO $27.04 0.00%


Chart of I:DJI
DOW 15,973.84 +313.66 2.00%
S&P 500 1,864.78 +35.70 1.95%
NASDAQ 4,337.5120 +70.6750 1.66%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs