6. 2013 Mercedes-Benz E-Class Sedan
Starting price: $51,900
An emergency monitoring service, driver-fatigue monitor, pre-collision automatic braking, blind-spot detection and a lane-departure warning system are all great reasons to make this a road-trip car, but they're not the reasons anyone who can afford it ever does.That Mercedes engine and handling make the driver feel more like a racer than a chauffeur. Meanwhile the four-seater's Comand entertainment, navigation and communication system, Comfort Box beverage storage, ventilated seats and rear DVD entertainment system should keep everyone else sated while their driver's at play.