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Hyperion Therapeutics Acquires Worldwide Rights To BUPHENYL

Please see full Prescribing Information for BUPHENYL at http://www.hyperiontx.com/product

RAVICTI Safety Information

RAVICTI is indicated for use as a nitrogen-binding agent for chronic management of adult and pediatric patients ≥2 years of age with UCDs who cannot be managed by dietary protein restriction and/or amino acid supplementation alone. RAVICTI must be used with dietary protein restriction and, in some cases, dietary supplements (e.g., essential amino acids, arginine, citrulline, protein-free calorie supplements). RAVICTI is not indicated for the treatment of acute hyperammonemia in patients with UCDs because more rapidly acting interventions are essential to reduce plasma ammonia levels. The safety and efficacy of RAVICTI for the treatment of N-acetylglutamate synthase (NAGS) deficiency has not been established. The use of RAVICTI in patients < 2 months of age is contraindicated.

For additional Important Safety Information, including Warnings and Precautions, Adverse Events, Drug Interactions, and Special Populations, please see full Prescribing Information ( http://www.ravicti.com/files/RAVICTI_Prescribing_Information.pdf ) and Medication Guide ( http://www.ravicti.com/files/RAVICTI_Medication_Guide.pdf ) for RAVICTI.

About Hyperion Therapeutics

Hyperion Therapeutics, Inc. is a commercial stage biopharmaceutical company committed to developing and delivering life-changing treatments for orphan diseases and hepatology. The company's first commercial product, Ravicti™(glycerol phenylbutyrate) Oral Liquid, was approved in February 2013 and is currently being marketed in the United States.

For more information, please visit www.hyperiontx.com .
CONTACT: Sylvia Wheeler
         Vice President, Investor Relations
         (650) 745-7834
         sylvia.wheeler@hyperiontx.com

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