This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Bristol And Merck's Cancer Drugs Won ASCO. Five Slides Explain Why.

CHICAGO ( TheStreet) -- The five most important slides from this weekend's American Society of Clinical Oncology (ASCO) annual meeting -- where the anti-PD-1 therapies from Bristol-Myers Squibb (BMY) and Merck (MRK) stole the show.

This isn't a chart of real data but it's the best slide of the ASCO meeting because it explains why cancer immunotherapy is winning over targeted therapies, particularly in melanoma. It's the long survival tail!

Targeted therapies work fast but responses tend to be transient as cancer cells develop resistance. This means that early, impressive survival benefit aren't sustainable.

Cancer immunotherapy, on the other hand, works slower. It takes time for the patient's immune system to identify and kill cancer cells. But once a patient's T-cells get a taste for cancer cells, their appetite is insatiable. That means tumor responses that are more durable and (hopefully) sustained and prolonged survival.

This is the summary slide of the tumor response data seen with Merck's anti-PD-1 therapy lambrolizumab in patients with advanced melanoma. Treatment with lambrolizumab results in 38 percent of melanoma patients overall having significant tumor shrinkage. In the best-performing dose group, 52 percent of patients responded.

Stunningly good results -- some of the best ever -- which is why a theater jam-packed with cancer experts Sunday were buzzing. During a Q&A session, one member of the audience commented (half-jokingly) that the lambrolizumab data were so convincing, the drug should just be approved now without any further clinical trials necessary.

This chart illustrates the durability of responses resulting from Merck's lambrolizumab therapy. See all those right-facing arrows? Those are patients still responding to treatment after 50, 60, even 70 weeks. More specifically, 81 percent of patients who had a response were still in the study receiving treatment with lambrolizumab at the time of the analysis. Amazing.

This slide helps explain why investors are treating Bristol-Myers like a biotech stock, with shares up more than 40 percent this year. Nivolumab has the potential to be a blockbuster melanoma drug, but even more enticing is the potential for the drug to re-write the lung cancer treatment playbook. Melanoma is a big commercial market but lung cancer is huge -- and Bristol-Myers is already enrolling lung cancer patients in three clinical trials that could be used to support approval.

Not to be outdone, Merck also announced plans to start late-stage studies of lambrolizumab in melanoma and lung cancer in the third quarter.

More long-tail survival data, these from nivolumab in melanoma. Impressive.

-- Reported by Adam Feuerstein in Chicago.

Follow Adam Feuerstein on Twitter.

Adam Feuerstein writes regularly for TheStreet. In keeping with company editorial policy, he doesn't own or short individual stocks, although he owns stock in TheStreet. He also doesn't invest in hedge funds or other private investment partnerships. Feuerstein appreciates your feedback; click here to send him an email.

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 17,279.74 +13.75 0.08%
S&P 500 2,010.40 -0.96 -0.05%
NASDAQ 4,579.7890 -13.6380 -0.30%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs