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Trius Announces Notice Of Allowance Of U.S. Patent Application Related To Tedizolid Phosphate Combination With Daptomycin

SAN DIEGO, May 13, 2013 (GLOBE NEWSWIRE) -- Trius Therapeutics, Inc. (Nasdaq:TSRX), a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for serious infections, announced today that it has received a Notice of Allowance from the U.S. Patent and Trademark Office (USPTO) on an application related to its tedizolid phosphate patent portfolio. This newly allowed patent application protects a therapeutic combination of the experimental medicine tedizolid phosphate with a currently available antibiotic daptomycin. Data show that together, the medicines can uniquely prevent the development of daptomycin non-susceptible bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA).

As detailed in the patent application, tedizolid phosphate, at concentrations substantially below its current therapeutic dose to treat skin infections, unexpectedly prevents the formation of daptomycin resistant mutants of Staphylococcus aureus. Tedizolid appears to be unique in this mutant prevention activity given that seven other medicines tested, including linezolid, the only other drug of the same class as tedizolid, failed to show the same mutant prevention activity.

"MRSA bacteremia is a potentially fatal disease with limited treatment options," said Ralph Corey, M.D. Professor of Medicine and Infectious Diseases at Duke University. "As a clinician who treats bacteremia patients, I am concerned by the growing resistance to one of our last effective treatment options, daptomycin, and welcome this news that tedizolid phosphate may prevent daptomycin resistance when used in a combination therapy."

"Given the recent positive Phase 3 results of tedizolid phosphate for the treatment of skin infections, we are eager to examine its potential, whether alone or in combination with other medicines, for the treatment of bacteremia," said Jeffrey Stein, Ph.D., President and Chief Executive Officer of Trius. "Most importantly, this patent, coupled with the results of our long-term safety studies, provide us with guidance on how best to expand the development of tedizolid phosphate to treat patients with severe bacterial infections requiring sustained treatment."

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