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Cell Culture: The Market For Media, Sera And Reagents, 5th Edition

CHAPTER ONE: EXECUTIVE SUMMARY Scope and Methodology Cells for Biopharmaceutical Production Bacteria and Yeasts Systems Animal Cell Systems Insect Cell Systems Cell Lines and Cell Banks Fermentors and Bioreactors Stirred-tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-Fiber Reactor Disposable Systems Fermentation Processes Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environment Functions and Components of Basal MediapH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media Lysogeny broth (LB) Classical Media Serum-free Media Protein-free Media Chemically Defined Media Specialty Media Sera Reagents Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety Issues World Cell Culture Market Cell Culture Market and Forecast Current And Future Trends CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT Growing Demand for Biopharmaceuticals Biopharmaceutical Market Development of Biopharmaceuticals Biopharmaceutical Growth Increases Demand for Cell Culture Products A Brief History of Biotechnology Science of Genetic Manipulation From Petri Dish to Biopharmaceutical Upstream Bioprocessing: Cell Culture Expression Systems Cells for Biopharmaceutical ProductionBacteria and Yeasts Systems Animal Cell Systems Insect Cell Systems Advantages/Disadvantages of Cell Culture Systems Cell Lines and Cell Banks Biopharmaceuticals Produced from Cell Culture Cell Culture Practices and Regulatory Guidelines Validation of Facilities Maintaining Sterilization Standards CHAPTER THREE: CELL CULTURE TECHNOLOGY Introduction and Overview Milestones in Cell Culture Development Cell Lines for Bioproduction Predominant Cell LinesChinese Hamster Ovary (CHO) SP2/0, and NS0 HEK 293 and PER. C6 Sources: Largest Collections of Cell Lines Fermentors and Bioreactors Types of Bioreactors/FermentorsStirred-tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-fiber Reactor Disposable Systems Fermentation Processes Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environment Functions and Components of Basal MediapH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media Types of MediaLysogeny broth (LB) Classical Media Serum-free Media Protein-free Media Chemically Defined Media Specialty Media Sera Sources of Sera Bovine Serum Safety Issues and Regulations Shift to Serum-free Media Reagents Major Types of Biologic ReagentsAmino Acids Growth Factors and Cytokines Albumin Transferrin Thrombin Growth Supplements Protease Inhibitor Attachment Factors Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety Issues CHAPTER FOUR: CELL CULTURE MARKET CURRENT AND FUTURE TRENDS Overview Cell Culture Market Market Drivers Cell Culture Market Forecast Market Segment Analysis Media Sera Reagents Cell Culture Suppliers' Market Share Current And Future Trends Shift to Serum-free and Animal Product-free MediaConcomitant Need for Animal-derived Media Cell Culture-based Vaccine ProductionCell Culture-based Vaccine on Market Stem Cell Research Driving Cell Culture MarketLife Technologies Sigma-Aldrich ThermoFisher Scientific Lonza Bioscience EMD Millipore BD Bioscience Impact of Generic Biopharmaceuticals on Cell Culture Market CHAPTER FIVE: COMPANY PROFILES Advanced Biotechnologies, Inc. History and Lines of Business Cell Culture Products and Services Affymetrix, Inc. History and Lines of Business Cell Culture Products, Reagents and BiochemicalsMolecular Biology Enzymes Molecular Biology Kits and Reagents Purification Biochemicals PCR Reagents Panomics Quantitative Assays eBioscience Immunology Reagents Financial Information AMRESCO, Inc. History and Lines of Business Cell Culture Products Analytical Biological Services Inc. History and Lines of Business Cell Culture ProductsMammalian Cell Culture Cell in Microtiter Plates for HTS Primary Cultures Insect Cell Culture Athena Enzyme Services History and Lines of Buiness Cell Culture Products Atlanta Biologicals, Inc. History and Lines of Business Cell Culture ProductsAnimal & Human Sera Media & Balanced Salts Supplements & Reagents Cell Separation Products Athena Enzyme Systems History and Lines of Business Cell Culture ProductsExpression Media Cell Culture Products Custom Cell Culture Media Enzyme Assays BD Biosciences History and Lines of Business Cell Culture ProductsClinical and Clinical Research Reagents, which include: Research Reagents, which include: Financial Information Bioreclamation Inc History and Lines of Business Cell Culture Products Cell Essentials, Inc. History and Lines of Business Cell Culture Products CellGenix Technologie Transfer GmbH History and Lines of Business Cell Culture Products and Services ClonTech Laboratories, inc. History and Lines of Business Cell Culture Products corning life sciences History and Lines of Business Cell Culture Products EMD Millipore History and Lines of Business Cell Culture Products Financial Information GE Heathcare Live Sciences History and Lines of Business Cell Culture Products Gemini Bio-Products History and Lines of Business Cell Culture ProductsCell Culture Sera Human Sera Specialized Media invitria History and Lines of Business Cell Culture ProductsCellastim Lacromin Optiferrin ITSE Animal-free Zap-CHO Zap-Hybridoma Irvine Scientific History and Lines of Business Cell Culture ProductsCell Culture Products Custom Media Program Express Media Service R&D Development Program J R Scientific, Inc. History and Development Cell Culture Products Life Technologies Corporation History and Lines of Business Cell Culture Products Financial Information Lonza Bioscience History and Lines of Business Cell Culture Products and ServicesCulture Media Development Cell Line Creation Cell Banking MP Biomedicals History and Lines of Business Cell Culture Products Novozymes Biopharma US Inc History and Lines of Business Cell Culture ProductsrAlbumin Albucult Albufuse and Albufuse Flex Yeast Expression Technology Growth Factors Bacillus-derived Hyaluronic Acid Purification Ligands Recombinant Tansferrin PromoCell GmbH History and Lines of Business Cell Culture Products Quality Biological, Inc. History and Lines of Business Cell Culture Products R&D Systems, Inc. History and Lines of Business Cell Culture Products SAFC Biosciences History and Lines of Business Cell Culture Products Financial Information SBH Sciences History and Lines of Business Cell Culture Products Selexis SA History and Lines of Business Cell Culture Products and Technology SeraCare Life Sciences, Inc. History and Lines of Business Cell Culture Products Sera Laboratories International Ltd History and Lines of Business Cell Culture ProductsProduct Categories Stemcell Technologies Inc. History and Lines of Business Cell Culture ProductsEmbryonic stem cells & induced pluripotent stem (iPS) cells Hematopoietic stem & progenitor cells Neural stem & progenitor cells Mammary epithelial cells Bronchial epithelial cells Prostate epithelial cells Thermo Fisher Scientific, Inc. History and Lines of Business Cell Culture Products Financial Information Wisent Bioproducts History and Lines of Business Cell Culture Products LIST OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY Exhibit 1-1Worldwide Cell Culture Market, 20112 CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT Exhibit 2-1Top Selling Biological Drugs in 2011 Exhibit 2-2Top Selling Biological Drugs in 2012 Exhibit 2-3FDA Biopharmaceutical Product Approvals, 2011 Exhibit 2-4FDA Biopharmaceutical Product Approvals, 2012 Exhibit 2-5Approximate times from Introduced Gene to Protein Production at Useable Levels Exhibit 2-6Disadvantages/Advantages of Cell Culture Systems Exhibit 2-7Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells CHAPTER THREE: CELL CULTURE TECHNOLOGY Exhibit 3-1Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma and CHO cell lines CHAPTER FOUR: CELL CULTURE MARKET CURRENT AND FUTURE TRENDS Exhibit 4-1Worldwide Cell Culture Market, 2007-2017 Exhibit 4-2Cell Culture World Market Share, by Region, 2012 Exhibit 4-3World Cell Culture Market by Segment: Media, Sera and Reagents, 2005-201571 Exhibit 4-4Breakout of Media Market (Serum-Free, CD, ADCF) Exhibit 4-5Cell Culture Market Share, 2012 To order this report: Cell Culture: The Market for Media, Sera and Reagents, 5th Edition Contact Clare: clare@reportlinker.comUS:(339) 368 6001Intl:+1 339 368 6001

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