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Patent Issued In China For EntreMed's Lead Drug Candidate ENMD-2076

ROCKVILLE, Md., May 6, 2013 /PRNewswire/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, today announced the issuance by the Chinese State Intellectual Property Office of Patent Certificate No. ZL 200680044656.7.  The granted claims are directed to ENMD-2076, covering composition of matter and uses to treat various cancers.  The patent is part of EntreMed's broad intellectual property portfolio for ENMD-2076.

(Logo:  http://photos.prnewswire.com/prnh/20010620/ENMDLOGO )

"We are very pleased with the issuance of this patent in China for ENMD-2076," said Ken K. Ren, Ph.D., the Company's Chief Executive Officer.  "This patent provides intellectual property protection for ENMD-2076 in a market that is experiencing tremendous growth and of which we intend to capitalize on.  The issuance of this patent broadens our existing international patent estate for ENMD-2076 and also confirms the Chinese State Intellectual Property Office's recognition that ENMD-2076 represents new and inventive chemical structures." 

ENMD-2076 has completed and shown activity in Phase 1 clinical trials in solid tumor cancers, leukemia, multiple myeloma, and is completing a Phase 2 trial for ovarian cancer.  A Phase 2 triple-negative breast cancer trial at the University of Colorado and Indiana University and a Phase 2 trial in advanced/soft tissue sarcoma at Princess Margaret Hospital are currently enrolling.  As part of its global development strategy utilizing China resources, EntreMed has submitted a new drug clinical trial application with the Chinese Food and Drug Administration (CFDA) for ENMD-2076 to conduct global clinical trials in triple-negative breast cancer patients. 

About EntreMed

EntreMed is a clinical-stage pharmaceutical company employing a drug development strategy primarily in the United States and China to develop targeted therapeutics for the global market.  Its lead compound, ENMD-2076, a selective angiogenic kinase inhibitor, has completed several Phase 1 studies in solid tumors, multiple myeloma, and leukemia, and is currently completing a multi-center Phase 2 study in ovarian cancer.  EntreMed is currently conducting a Phase 2 study of ENMD-2076 in triple-negative breast cancer and a Phase 2 study of ENMD-2076 in advanced/metastatic soft tissue sarcoma.  The Company is headquartered in Rockville, Maryland and has local operations in Beijing, China.  Additional information about EntreMed is available on the Company's web site at www.entremed.com and in various filings with the Securities and Exchange Commission (the SEC).

About ENMD-2076

ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action.  ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase.  Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers.  ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers.  ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid tumor cancers, leukemia, and multiple myeloma, and is currently completing a Phase 2 trial for ovarian cancer.  EntreMed is currently conducting a dual-institutional Phase 2 study of ENMD-2076 in triple-negative breast cancer and a Phase 2 study in advanced/metastatic soft tissue sarcoma. ENMD-2076 has received orphan drug designation from the FDA for the treatment of ovarian cancer, multiple myeloma and acute myeloid leukemia.

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