May 6, 2013
/PRNewswire/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, today announced the issuance by the Chinese State Intellectual Property Office of Patent Certificate No. ZL 200680044656.7. The granted claims are directed to ENMD-2076, covering composition of matter and uses to treat various cancers. The patent is part of EntreMed's broad intellectual property portfolio for ENMD-2076.
"We are very pleased with the issuance of this patent in
for ENMD-2076," said
Ken K. Ren
, Ph.D., the Company's Chief Executive Officer. "This patent provides intellectual property protection for ENMD-2076 in a market that is experiencing tremendous growth and of which we intend to capitalize on. The issuance of this patent broadens our existing international patent estate for ENMD-2076 and also confirms the Chinese State Intellectual Property Office's recognition that ENMD-2076 represents new and inventive chemical structures."
ENMD-2076 has completed and shown activity in Phase 1 clinical trials in solid tumor cancers, leukemia, multiple myeloma, and is completing a Phase 2 trial for ovarian cancer. A Phase 2 triple-negative breast cancer trial at the
University of Colorado
and a Phase 2 trial in advanced/soft tissue sarcoma at Princess Margaret Hospital are currently enrolling. As part of its global development strategy utilizing
resources, EntreMed has submitted a new drug clinical trial application with the Chinese Food and Drug Administration (CFDA) for ENMD-2076 to conduct global clinical trials in triple-negative breast cancer patients.
EntreMed is a clinical-stage pharmaceutical company employing a drug development strategy primarily in
the United States
to develop targeted therapeutics for the global market. Its lead compound, ENMD-2076, a selective angiogenic kinase inhibitor, has completed several Phase 1 studies in solid tumors, multiple myeloma, and leukemia, and is currently completing a multi-center Phase 2 study in ovarian cancer. EntreMed is currently conducting a Phase 2 study of ENMD-2076 in triple-negative breast cancer and a Phase 2 study of ENMD-2076 in advanced/metastatic soft tissue sarcoma. The Company is headquartered in
and has local operations in
, China. Additional information about EntreMed is available on the Company's web site at
and in various filings with the Securities and Exchange Commission (the SEC).
ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers. ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid tumor cancers, leukemia, and multiple myeloma, and is currently completing a Phase 2 trial for ovarian cancer. EntreMed is currently conducting a dual-institutional Phase 2 study of ENMD-2076 in triple-negative breast cancer and a Phase 2 study in advanced/metastatic soft tissue sarcoma. ENMD-2076 has received orphan drug designation from the FDA for the treatment of ovarian cancer, multiple myeloma and acute myeloid leukemia.