LOS ANGELES, May 3, 2013 /PRNewswire/ -- Michael Feiz, M.D., FACS is renowned throughout Southern California for performing life-changing weight loss procedures such as FDA compliant lap band surgery. One of the most effective procedures of Dr. Feiz, the sleeve gastrectomy, helps patients lose weight by removing large portions of the fundus, which contains the ghrelin hormone that causes the hunger cravings that often make weight loss so difficult. However, in addition to their success in promoting weight loss, new evidence shows that many of these procedures are leading to other major health benefits as well.
More research will be needed before it is known precisely why gastric bypass surgery has been found to induce early remission of type 2 diabetes in the vast majority of patients, according to a report from the Society for Endocrinology. "We provide evidence that in severely obese people, the levels of specific genes that control how fat is burned and stored in the body are changed to reflect poor metabolic health," says Professor Juleen Zierath, senior author of the study. Zierath continues, "After surgery, the levels of these genes are restored to a healthy state, which mirrors weight loss and coincides with overall improvement in metabolism."
A deeper investigation into the results of the study found that weight loss after surgery actually caused changes at a genetic level, leading to modifications among the DNA that control gene expression in response to the environment. In particular, chemical markings on two genes that control glucose and fat metabolism correlated with obesity are reversed after surgery-induced weight loss. Scientists are already suggesting that the findings may be useful for the design of new drugs that mimic the weight-loss-associated control of gene regulation. For the medical professionals at Dr. Feiz and Associates, this is exciting news.