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World's first licensed naloxone product for use by non-healthcare profession individuals in a community setting
Prenoxad Injection is a pre-filled syringe containing 1mg/ml naloxone hydrochloride solution for injection
Martindale Pharma, a leader in the manufacture and supply of specialty pharmaceuticals, is pleased to announce the UK launch of Prenoxad Injection, the world's first licensed emergency treatment for acute opioid related overdose for use at home or other non-medical settings
Prenoxad Injection is a Prescription Only Medicine (POM) containing a solution of naloxone hydrochloride. It is intended for emergency use for the complete or partial reversal of life-threatening respiratory depression following the administration of natural or synthetic opioids. Naloxone is an 'opioid antagonist' medicine with an excellent safety and efficacy profile following use over more than four decades
Prenoxad Injection will be made available to people who are at risk of opioid related overdose or to their nominated client or representative
1. It will be administered as part of an emergency resuscitation intervention in suspected overdose casualties and must be used in combination with other basic life support measures. The use of Prenoxad Injection should always be preceded by calling emergency services and requesting an ambulance.
There are more than 1,000 fatal opioid related overdoses in the UK each year alone, with a significant proportion of these being witnessed by other people who use drugs, family members and loved ones. It is recognised that the availability of naloxone at the scene of the overdose can help to reduce this figure
The UK Government
3, and each of the devolved administrations
4,5,6 have identified overdose and drugs related deaths as a significant public health concern and reducing these deaths is a key goal. The provision of naloxone to people at risk of overdose is already underway in
Northern Ireland on a national basis, with many local programmes in existence across
May 2012 the Advisory Council on Misuse of Drugs (ACMD) published a report on naloxone including the recommendation that: "
Naloxone should be made more widely available to tackle the high numbers of fatal opioid overdoses in the UK2."
Martindale Pharma has developed Prenoxad Injection following extensive consultation and networking with those responsible for commissioning and delivering outcome focused recovery orientated services, as well as the people who use these services.