SALT LAKE CITY, May 2, 2013 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (Nasdaq:MYGN) today highlighted new clinical data on the PROLARIS 46-gene cell cycle progression (CCP) signature in patients with prostate cancer that will be presented at this year's American Urological Association (AUA) in San Diego.
"We have realized for some time that current clinical-pathologic features, while informative, are still inadequate in determining prostate cancer aggressiveness for an individual," said Michael Brawer, vice president of Medical Affairs at Myriad. "Every corner of the healthcare system including providers, payors, patients and health policy experts are asking for a test that can better determine prostate cancer aggressiveness and give more precise guidance of management options."
The clinical studies being presented at AUA focus on PROLARIS test results in patients who underwent radical prostatectomy or who were treated with external beam radiation therapy. In both of these prospectively-designed studies, the PROLARIS signature consistently demonstrated additional prognostic utility beyond what is available from standard clinical parameters such as Gleason score, prostate specific antigen (PSA) level and clinical stage."The PROLARIS signature is the dominant variable at diagnosis in predicting risk of prostate cancer progression, as determined by the gold standard oncologic endpoints such as biochemical recurrence, metastasis and prostate cancer death," said Brawer. "The PROLARIS score can provide personalized risk of cancer progression above that afforded by the Gleason score, clinical stage and PSA level. This information can help clinicians identify patients who are good candidates for conservative management and patients for whom monotherapy with surgery or radiation therapy may be inadequate." These findings complement clinical data previously published in the peer-reviewed scientific literature. Myriad's PROLARIS test is the only commercial product that predicts prostate cancer death and has been evaluated in nine clinical studies with more than 3,000 patients. PROLARIS also is the only product that can be used in multiple sample types giving it applicability in both pre-treatment biopsy specimens and radical prostatectomy samples.
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