ROCKVILLE, Md., April 18, 2013 /PRNewswire/ -- Neuralstem, Inc. (NYSE MKT: CUR) announced that CEO and President, Richard Garr, will take part in a comprehensive Bio Maryland panel, introduced by Lt. Governor, Anthony Brown, on Maryland's leadership in traumatic brain injury prevention, diagnosis and treatment at the BIO International Convention in Chicago, Ill., on April 24. Mr. Garr's panel, from 2:30 – 3:30, will discuss "Treatment—What's Working and What is Under Development." He will focus on NSI-189, Neuralstem's lead neurogenic compound, which is currently in a Phase Ib clinical trial in major depressive disorder (MDD). In animal models of depression, NSI-189 significantly increased the generation of new neurons in the hippocampus, a part of the brain that atrophies in patients who have major depression and which could also be implicated in brain injury. Mr. Garr will also talk about the potential of NSI-189 to be used in the treatment of traumatic brain injury (TBI).
Neuralstem's patented technology enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glia. Neuralstem completed an FDA-approved Phase I safety clinical trial for amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's disease, in February 2013, and has received FDA approval to begin Phase II. Neuralstem has been awarded orphan status designation by the FDA for its ALS cell therapy.In addition to ALS, the company is also targeting major central nervous system conditions with its NSI-566 cell therapy platform, including spinal cord injury, ischemic stroke and glioblastoma (brain cancer). The company received approval to commence a Phase I safety trial in chronic spinal cord injury in January 2013. Neuralstem also has the ability to generate stable human neural stem cell lines suitable for the systematic screening of large chemical libraries. Through this proprietary screening technology, Neuralstem has discovered and patented compounds that may stimulate the brain's capacity to generate new neurons, possibly reversing the pathologies of some central nervous system conditions. The company is in a Phase Ib safety trial evaluating NSI-189, its first neurogenic small molecule compound, for the treatment of major depressive disorder (MDD). Additional indications could include traumatic brain injury (TBI), Alzheimer's disease, and post-traumatic stress disorder (PTSD).
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