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Results From Cardio3BioSciences C-CURE® Trial Published In The Journal Of The American College Of Cardiology

Cardio3 BioSciences is a Belgian leading biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac diseases. The company was founded in 2007 and is based in the Walloon region of Belgium. Cardio3 BioSciences leverages close research collaborations in the US with Mayo Clinic and in Europe with the Cardiovascular Centre Aalst, Belgium.

The Company's lead product candidate C3BS-CQR-1 is the most advanced autologous cellular therapy product for the treatment of heart failure, one of the world's most pressing unmet medical needs.  The product consists of patient's own stem cells harvested from the bone marrow and engineered to become progenitors of new functional cardiac cells that behave identically to those lost to heart disease with a goal to rebuild the heart. This process of cardiac-linage commitment is known as Cardiopoiesis. CQR-1 is currently the first product in a Phase III trial worldwide using organ specified cells for the treatment of ischemic heart failure.

Cardio3 BioSciences has also developed C-Cath® ez, the technologically most advanced intra-myocardial injection catheter with superior performance for delivery of biotherapeutics into the myocardium.  The proprietary steerable percutaneous catheter has been developed to elevate the standard of care to clinicians and patients.  C-Cath ez® is CE marked and is now available for commercial use in the EU and many other countries where the CE mark allows commercialization.

Disclosures

In accordance with the Bayh-Dole Act, Mayo Clinic has licensed the technology underlying C3BS-CQR-1 (formerly C-Cure) to Cardio3 BioSciences and received an equity position in the company in the context of the license. Mayo Clinic and the inventors of the technology, Drs. Andre Terzic and Atta Behfar, have a financial interest associated with the technology related to this research. While no royalties have accrued to date, Mayo Clinic has rights to receive future royalties which will be shared with Drs. Terzic and Behfar in accordance with the Mayo Clinic Royalty sharing policy.

C3BS-CQR-1, C-Cure, C-Cath, Cardio3 BioSciences and the Cardio3 BioSciences and C-Cath logos are trademarks or registered trademarks of Cardio3 BioSciences SA, in Belgium, other countries, or both. In addition to historical facts or statements of current condition, this press release contains forward-looking statements, which reflect our current expectations and projections about future events, and involve certain known and unknown risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. These forward-looking statements are further qualified by important factors, which could cause actual results to differ materially from those in the forward-looking statements, including timely submission and approval of anticipated regulatory filings; the successful initiation and completion of required Phase III studies; additional clinical results validating the use of adult autologous stem cells to treat heart failure; satisfaction of regulatory and other requirements; and actions of regulatory bodies and other governmental authorities. As a result, of these factors investors and prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or review any forward-looking statement, whether as a result of new information, future events or otherwise.

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