BERKELEY HEIGHTS, N.J., April 9, 2013 (GLOBE NEWSWIRE) -- Cyclacel Pharmaceuticals, Inc. (Nasdaq:CYCC) (Nasdaq:CYCCP) ("Cyclacel" or the "Company") today announced updated data from an open label, single arm, Phase 1 escalation trial of the Company's two product candidates, sapacitabine, a nucleoside analogue, and seliciclib, a cyclin-dependent kinase (CDK) inhibitor, as an orally-administered sequential treatment regimen in heavily-pretreated patients with advanced solid tumors. Data were presented as an oral presentation during the 104 th Annual Meeting of the American Association of Cancer Research (AACR) 2013 in Washington, D.C.
"We are encouraged by the responses seen with the sequential administration of sapacitabine and seliciclib in patients who carry a BRCA mutation," said Geoffrey Shapiro, M.D., Director, Early Drug Development Center, Dana-Farber Cancer Institute and Associate Professor, Department of Medicine, Harvard Medical School. "Our findings have shown that some patients who carried a BRCA mutation achieved durable partial responses and prolonged stable disease by this treatment regimen."
"The promising findings of Dr. Shapiro's work on the Phase 1 study show that sequential treatment with sapacitabine and seliciclib is tolerable and active," said Judy Chiao, M.D., Vice President Clinical Development and Regulatory Affairs of Cyclacel. "This clinical observation may be directly related to the drugs' mechanism of action acting on the ability of cancer cells to undergo DNA repair through the homologous recombination or HR pathway. If these preliminary findings are confirmed by further work, these drugs may provide an important treatment alternative for patients with BRCA-deficient cancers."Based on these emerging results, the investigators continue to enroll an enriched population of patients who carried a BRCA mutation in the trial, in whom the combination has been most efficacious. Additional schedules of the combination therapy are under evaluation. BRCA mutation carrier status and homologous recombination defect (HRD) status may be potential biomarkers for response to this combination across multiple tumor types.
Select the service that is right for you!COMPARE ALL SERVICES
Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
- Weekly roundups
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
- Upgrade/downgrade alerts
Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
- Diversified model portfolio of dividend stocks
- Alerts when market news affect the portfolio
- Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.
- Real Money + Doug Kass Plus 15 more Wall Street Pros
- Intraday commentary & news
- Ultra-actionable trading ideas
Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
- 100+ monthly options trading ideas
- Actionable options commentary & news
- Real-time trading community
- Options TV