Drug Interactions: Avoid concurrent use with strong or moderate CYP3A inhibitors or inducers.
Proton Pump Inhibitors (PPIs): Consider using short-acting antacids or H2 blockers instead of PPIs. Separate antacid or H2 blocker dosing and BOSULIF dosing by more than 2 hours.
Substrates of P-glycoprotein: BOSULIF may increase the plasma concentrations of drugs that are P-gp substrates, such as digoxin.
Nursing Mothers: Given the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or BOSULIF.Hepatic Impairment: Treat with a dose of 200 mg daily in patients with any baseline hepatic impairment. For more information and full prescribing information, please visit www.pfizer.com. About Pfizer Oncology Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Hematologic cancers are a complex group of diseases, with over 70 different types of lymphomas, leukemias or myelomas. While there have been significant advancements in the treatment of some hematologic cancers, there continues to be a need for additional therapeutic options. Pfizer Oncology is committed to improving outcomes for patients living with hematologic malignancies like CML. Pfizer Oncology has a robust hematology pipeline, with biologics and small molecules in clinical development across a number of hematologic malignancies. We are advancing technologies as well as working to identify new and innovative options that address specific hematologic cancers, molecular subtypes, gene over-expression and mechanisms of resistance. For more information, please visit www.Pfizer.com. DISCLOSURE NOTICE: The information contained in this release is as of March 28, 2013. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. This release contains forward-looking information that involves substantial risks and uncertainties about an oncology product, BOSULIF. Such risks and uncertainties include, among other things, whether and when the European Commission (EC) will convert the conditional marketing authorization for BOSULIF to a full marketing authorization in the EU, as well as the EC’s decisions regarding labeling and other matters that could affect BOSULIF’s availability or commercial potential in the EU; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2012 and in its reports on Form 10-Q and Form 8-K. 1 Summary of Product Characteristics (SmPC) for BOSULIF®. Sandwich, Kent: UK; 2013. 2 Konig H. Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells. Cancer Research. 2008; 68: 9624-9633. 3 BOSULIF® (bosutinib) Prescribing Information. New York, NY: Pfizer, Inc.; 2012.
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