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Regenerative Medicine Markets

10. Company Profiles 16710.1. Aastrom Biosciences, Inc. 16710.1.1 Aastrom's Cellular Therapy and Ixmyelocel-T 16710.1.1.1 Advantages of Patient's Bone Marrow and Ixmyelocel-T 16710.1.2 Aastrom's Clinical Trials 16810.1.2.1 REVIVE-CLI 16810.1.2.2 RESTORE-CLI 16810.2 Advanced Cell Technology, Inc. (ACT) 16810.2.1 ACT's Human ES Cell Programs 16910.2.2 ACT's Human Embryonic Stem Cell Technologies 16910.2.3 ACT's Cell Therapy Research Program 17010.2.3.1 Retinal Pigment Epithelium Program 17010.2.3.2 Hemangioblast Program 17010.2.3.3 Adult Stem Cell Program 17010.2.4 ACT's Intellectual Property 17110.3 AlloCure, Inc. 17210.3.1 AlloCure's Technology 17210.3.2 AlloCure's Clinical Trials 17310.3.2.1 Acute Kidney Injury 17310.3.2.2 Epidemiological Study of AKI 17310.3.2.3 Phase I Clinical Trial in AKI 17410.3.2.4 Phase II Clinical Trial in AKI 17410.4 Altrika Ltd. 17410.4.1 Myskin 17410.4.2 Cryoskin 17410.5 American Type Culture Collection, Inc. (ATCC) 17510.5.1 ATCC's Cell Lines and Hybridomas 17510.5.2 ATCC's Media, Sera and Reagents 17510.5.3 MTT Cell Proliferation Assay 17510.5.4 XTT Cell Proliferation Assay Kit 17510.5.5 Universal Mycoplasma Detection Kit 17610.5.6 DNA and RNA 17610.5.7 STR Profile Database 17610.5.8 hTERT Immortalized Cell Lines 17610.5.9 Embryonic Stem Cell Products 177 10.5.10 Bacteria and Phages 177 10.5.11 Fungi and Yeast 177 10.5.12 Protozoa and Algae 177 10.5.13 Viruses and Related Reagents 177 10.5.14 Microbial DNA and RNA 178 10.5.15 ATCC's Tissue Biology Products 17810.6 Avita Medical Limited 17810.6.1 ReCell 17810.7 Amorcyte, LLC 17810.7.1 AMR-001 179 10.8 Ars Arthro AS 17910.8.1 CaReS 17910.8.2 Fibrocell 17910.8.3 Fibroplus 17910.9 Axiogenesis AG 17910.9.1 Human iPS Cell-Derived Cardiomyocytes 18010.9.2 Murine Cardiomyocytes ES 18010.9.3 Murine Cardiomyocytes iPS 18010.9.4 Murine Endothelial Cells 18010.9.5 Murine Smooth Muscle Cells 18110.10 AxoGen, Inc. 18110.10.1 Avance Nerve Graft 18110.10.2 AxoGuard Nerve Protector 18210.10.3 AxoGuard Nerve Connector 18210.11 Bellicum Pharmaceuticals, Inc. 18210.11.1 Bellicum's Technology 18310.11.2 Bellicum's Pipeline 18410.12 BetaStem Therapeutics, Inc. 18410.12.1 BetaStem's Technology 18510.13 Bioheart, Inc. 18510.13.1 MyoCell 18510.13.2 MyoCell SDF-1 18610.13.3 MyoCath 18610.13.4 LipiCell 18610.14 Biomet, Inc. 18710.14.1 Endobon Xenograft Granules 18710.14.2 RegenerOss Allograft 18810.14.3 Ground Cancellous Bone 18810.15 BioMimetic Therapeutics, Inc. 18910.15.1 Augment Bone Graft 19010.15.2 Augmatrix Biocomposite Bone Graft 19010.16 BioTissue Technologies AG 19110.16.1 BioSeed-C 19110.16.2 Chondrotissue 19110.16.3 BioSeed-Oral Bone 19210.17 Biovest International, Inc. 19210.17.1 Autovaxid 19210.17.2 Xcellerator 19310.17.3 Maximizer 19310.17.4 Minimax 19310.18 BrainStorm Cell Therapeutics, Inc. 19310.18.1 NurOwn 19410.19 California Stem Cell, Inc. 19410.19.1 Clinical Pipeline 19410.19.1.1 MotorGraft 19410.19.1.2 Cancer Stem Cell 19410.19.2 Cell Products 19510.19.2.1 MotorPlate and MotorVial 19510.19.2.2 NeuroPlate and NeuroVial 19510.19.2.3 OPCVial 19510.19.2.4 HepatoPlate 19610.19.3 Cell Culture Products 19610.19.3.1 StemBlast 19610.19.3.2 MotorBlast 19610.19.3.3 NeuroBlast 19710.19.3.4 OPC Media 19710.19.3.5 Cellular Transplant Solution 19710.20 Cardio3 Biosciences SA 19710.20.1 Products Pipeline 19810.20.1.1 C3BS-CQR-1 (C-Cure) 19810.20.1.2 Positive Phase II Results for C-Cure 19810.20.1.3 C3BS-CQR-1 (Protein) 19810.20.1.4 C-CATHez (Medical Device) 19810.21 Cellartis AB (Cellectis) 19910.21.1 iPS Engineering Hub 19910.21.2 Hepatocytes hiPS-HEP 19910.21.3 Cardiomyocyte Clusters hES-CMC 20010.21.4 Stem Cell Culture System DEF-CS 20010.22 CellSeed, Inc. 20010.22.1 Epithelial Cell Sheet for Corneal Regeneration 20010.22.2 Regenerated Cardiac Patch 20110.22.3 Epithelial Cell Sheet for Esophageal Regeneration 20110.22.4 Cell Sheet for Periodontal Regeneration 20110.22.5 Regenerated Cartilage Sheet 20110.23 Cellular Dynamics International, Inc. 20110.23.1 iCell Cardiomyocytes 20210.23.2 iCell Endometrial Cells 20210.23.3 iCell Hepatocytes 20210.23.4 iCell Neurons 20210.23.5 MyCell Products 20210.24 Chromocell Corporation 20310.24.1 Chromovert Technology 20310.24.2 Chromovert Applications 20310.24.2.1 Pain Relief 20310.24.2.2 Anxiety Treatments 20410.24.2.3 Respiratory Disorders 20410.25 Cognate Bioservices, Inc. 20410.25.1 Process Development 20410.25.2 Regulatory Services 20410.25.3 Assay Development 20510.25.4 Preclinical Services 20510.25.5 Stem Cell Services 20610.26 Cook Biotech, Inc. 20610.26.1 Cook's Technology 20610.26.2 Biodesign Dural Graft 20710.26.3 Dynamatrix Extracellular Membrane 20710.26.4 tarSys 20710.26.5 Oasis Wound Matrix 20710.26.6 Biodesign Staple Line Reinforcement 20810.26.7 Biodesign Hiatal Hernia Graft 20810.26.8 CorMatrix ECM 20810.26.9 ECM for Cardiac Tissue Repair 209 10.26.10 Biodesign Incision Graft 209 10.26.11 Biodesign Inguinal Hernia Graft 209 10.26.12 Biodesign Parastomal Reinforcement Graft 210 10.26.13 Biodesign Umbilical Hernia Graft 210 10.26.14 Biodesign Anterior Pelvic Floor Graft 210 10.26.15 Biodesign Fistula Plug 211 10.26.16 LIFT with Biodesign 211 10.26.17 Biodesign Posterior Pelvic Floor Graft 211 10.26.18 Biodesign Peyronie's Repair Graft 212 10.26.19 Biodesign Tension-Free Urethral Sling 21210.27 Cytomedix, Inc. 21210.27.1 Cytomedix's AutoloGel System 21310.27.1.1 The Working of AutoloGel System 21310.27.1.2 Balancing Effect of AutoloGel System 21310.27.1.3 Formulation of AutoloGel System 21410.27.2 Cytomedix's Angel PRP 21410.28 Cytonet, LLC 21510.28.1 Cytonet's Liver Cell Therapy 21510.28.2 SELICA III Clinical Trial 21510.29 Cytori Therapeutics, Inc. 21510.29.1 Cytori's Commercial Activities and Markets 21510.29.2 Cytori's Pipeline 21610.29.2.1 Celution System for Cardiovascular Disease 21610.29.2.2 Other Applications of Celution System 21710.29.2.3 PureGraft 21710.29.2.4 StemSource 21710.30 DanDrit Biotech A/S 21810.30.1 Dendritic Cell 21810.30.1.2 Colorectal Cancer Trial Phase II in Singapore 21910.30.1.3 Non-Small-Cell Lung Cancer, Phase II 21910.31 Fibrocell Science, Inc. 21910.31.1 Fibrocell's Technology 22010.31.2 Pipeline 22010.32 Forticell Bioscience, Inc. 22010.32.1 OrCel 22010.33 Gamida Cell Ltd. 22110.33.1 Gamida's Technology 22110.33.1.1 Copper Chelator Based Technology 22110.33.1.2 NAM Based Technology 22110.33.1.3 StemEx 22210.33.1.4 NiCord 22210.33.1.5 CordBridge 22310.33.1.6 NK Cell Product 22310.34 Harvest Technologies Corporation 22310.34.1 Smart PReP2 APC+ 22310.34.2 SmartPReP 2 BMAC 22410.35 Histogenics Corporation 22410.35.1 NeoCart 22410.35.2 VeriCart 22610.36 Humacyte, Inc. 22610.36.1 Humacyte Grafts 22610.37 Integra Lifesciences Holdings Corporation 22710.37.1 Integra's Products Overview 22710.37.2 Integra's Orthopedics Product Portfolio 22710.37.3 Integra's Extremity Reconstruction Product Portfolio 22710.37.3.1 Skin and Wound 22710.37.3.2 Bone and Joint Fixation Devices and Instruments 22810.37.3.3 Lower Extremity Products 22810.37.3.4 Upper Extremity Products 22810.37.3.5 Bone Graft Substitutes for Extremity Reconstruction 22810.37.3.6 Nerve and Tendon 22810.37.4 Integra's Spine Product Portfolio 22810.37.4.1 Integrated Interbody Fusion Devices 22910.37.4.2 Minimally Invasive Solutions 22910.37.4.3 Deformity Correction 22910.37.4.4 Orthobiologics 22910.37.4.5 Integra's Research and Development in Regenerative Medicine 22910.38 Intercytex Ltd. 22910.38.1 VAVELTA 23010.38.2 Epidermolysis Bullosa 23010.38.3 Scar Contractures 23110.38.4 Acne Scarring 23110.38.5 International Stem Cell Corporation 23110.38.6 Therapeutic Programs 23210.39 iPierian, Inc. 23210.39.1 Technology 23310.39.2 Product Development 23310.40 Japan Tissue Engineering Co., Ltd. 23310.40.1 Autologous Cultured Epidermis 23310.40.2 Autologous Cultured Cartilage 23410.40.3 Autologous Cultured Corneal Epithelium 23510.41 Kensey Nash Corporation 23510.41.1 Medeor Matrix 23610.41.2 Meso BioMatrix Scaffold 23610.41.3 Epi-Guide Bioresorbable Barrier Matrix 23610.41.4 OsseoFit Porous Tissue Matrix 23710.41.5 Vitoss Scaffold Foam Products 23710.42 Kiadis Pharma B.V. 23710.42.1 Kiadis' Pipeline 23810.42.1.1 ATIR 23810.42.1.2 Reviroc 23910.42.1.3 Rhitol 24010.43 Living Cell Technologies Limited (LCT) 24010.43.1 Diabecell 24010.43.2 Ntcell 24010.44 Life Cell Corporation 24110.44.1 AlloDerm 24110.44.2 Cymetra Micronized AlloDerm Tissue 24110.44.3 Strattice Reconstructive Tissue Matrix 24210.44.4 SPY Elite System 24210.45 MaxCyte, Inc. 24310.45.1 MaxCytes Technology Platform 24310.45.2 Drug Discovery Applications 24310.45.2.1 GPCRs 24310.45.2.2 Ion Channels 24310.45.3 Antibody Production 24410.45.4 General Protein Production 24410.45.5 Viral Vector and VLP Production 24410.45.6 Insect Cell Transfection 24410.45.7 Cell Therapy 24410.45.7.1 Dendritic Cell Vaccines 24410.45.7.2 Regenerative Medicine 24510.45.7.3 Chimeric Antigen Receptor (CAR) Immunotherapy 24510.46 MediStem, Inc. 24510.46.1 Intellectual Property 24610.46.1.1 Method for Expansion of Stem Cells 24610.46.1.2 Compositions of Placentally-Derived Stem Cells for the Treatment of Cancer 24610.46.1.3 Transcatheter Tumor Immunoembolization 24610.46.1.4 Stem Cell Therapy for Cardiac Valvular Dysfunction 24610.46.1.5 Treatment of Erectile Dysfunction by Stem Cell Therapy 24610.46.1.6 Allogeneic Stem Cell Transplants in Non-Conditioned Recipients 24610.46.1.7 Stem Cell Mediated Treg Activation for Therapeutic Immune Modulation 24710.46.1.8 Cellular Therapy for Lower Back Pain 24710.46.1.9 Compositions and Methods of Stem Cell Therapy for Autism 24710.46.1.10 Stem Cell Therapy for Weight Loss 24710.46.1.11 Menstrual Blood Cellular Populations, Isolation, and Use Thereof 24710.46.1.12 Endometrial Derived Reparative/Regenerative Cells 24710.46.1.13 Treatment of Insulin Resistance and Diabetes 24810.46.1.14 Combination Treatment of Cardiovascular Disease 24810.46.1.15 Stem Cell Therapy for Autism 24810.46.2 Product Pipeline 24810.46.2.1 Endometrial Regenerative Cell Platform 24810.46.2.2 Angiostem Platform 24810.46.2.3 Tolerostem Platform 24810.47 Mesoblast Ltd. 24910.47.1 Revascor 24910.47.2 MPCs for Diabetics 24910.47.3 Bone Marrow Derived Allogeneic MPCs 24910.47.4 Macular Degeneration 25010.47.5 Diabetic Macular Edema 25010.47.6 Intervertebral Disc Repair Product 25010.47.7 Lumbar and Cervical Spinal Fusion Product 25110.47.8 Fracture Repair Product 25110.47.9 Arthritis Product 25110.48 MolMed S.p.A. 25210.48.1 MolMed's Technological Platforms 25310.49 NanoCor Therapeutics, Inc. 25310.49.1 Carfostin 25310.50 Neuralstem, Inc. 25310.50.1 Neuralstem's Technology Platforms: Stem Cells 25310.50.2 Pharmaceutical Compounds 25410.50.3 Neuralstem's Clinical Trials for Stem Cells 25510.50.4 Clinical Trials for Neuralstem's Pharmaceutical Compound 25510.51 NeuroNova AB 25510.51.1 Neurogenesis Qualifier 25510.51.2 NeuroNova's Projects 25610.52 Olympus Terumo Biomaterials Corp. 25610.52.1 OSferion60 25610.52.2 Terudermis 25610.52.3 OSferion 25810.52.4 Teruplug 25810.52.5 Bone Cream 25810.53 NewLink Genetics Corporation 25810.54 OncoMed Pharmaceuticals, Inc. 25910.54.1 OncoMed's Research on Cancer Stem Cells 25910.54.2 OncoMed's Platform 26010.54.3 OncoMed's Development Pipeline 26010.55 Opexa Therapeutics, Inc. 26110.55.1 T-Cell Platform 26110.56 Organogenesis, Inc. 26110.56.1 Apligraf 26110.56.2 Gintuit 26210.57 Orthovita, Inc. 26210.57.1 Vitoss 26310.58 Osiris Therapeutics, Inc. 26310.58.1 Osiris' Technologies 26410.58.1.1 Stem Cell Source 26410.58.1.2 Manufacturing Process 26410.59 Osteotech, Inc. 26510.59.1 MagniFuse 26510.59.2 Plexur P 26510.59.3 Plexur M 26610.59.4 FacetLinx Fusion Technology 26610.59.5 Grafton 26610.59.6 Xpanse Bone Inserts 26710.59.7 GraftCage TLX and GraftCage ACX 26710.60 Pervasis Therapeutics, Inc. 26710.61 Pluristem Therapeutics, Inc. 26810.62 Proneuron Biotechnologies, Inc. 26910.62.1 Spinal Cord Technology 26910.63 RegeneRx 27010.63.1 Tß4 Peptide Research 27010.64 ReNeuron Group PLC 27110.64.1 ReN001 27110.64.2 ReN009 27110.64.3 ReNcell VM and ReNcell CX 27210.65 Revivicor, Inc. 27210.65.1 Xenotransplantation Technology 27210.66 SanBio, Inc. 27310.66.1 SanBio's Product Pipeline 27310.66.1.1 SB623 27310.66.1.2 SB618 27310.66.1.3 SB308 27310.67 Saneron CCEL Therapeutics, Inc. 27410.67.1 U-Cord Cell Program 27410.67.2 Sert-Cell Program 27410.68 Sangamo Biosciences, Inc. 27410.68.1 SB-728 27410.68.2 SB-313 27510.68.3 Hemophilia 27510.69 Stem Cell Authority Ltd. 27510.69.1 MIRACHYMAL Stem Cells 27510.70 StemCells, Inc. 27510.70.1 StemCells' Research Collaborations 27610.70.1.1 Stanford University and Stanford School of Medicine 27610.70.1.2 UC Irvine 27610.70.1.3 OHSU Casey Eye Institute 27610.70.1.4 McLaughlin Research Institute 27610.70.2 StemCells' Therapeutic Programs 27610.70.3 Cells and Cell Lines 27710.70.4 Cell Culture Products 27710.70.5 Antibody Detection Reagents 27710.70.6 Purified Whole Stem Cell Lysates 27710.71 Stemline Therapeutics, Inc. 27810.71.1 Cancer Stem Cells 27910.71.2 Stemline Therapeutics' Platform 27910.72 Stratetech Corporation 27910.72.1 Stratatech's Core Technology 27910.73 Synthecon, Inc. 28010.73.1 Rotary Cell Culture Systems 28010.73.2 Biofelt (Bioabsorbable Scaffold) 28110.73.3 Biomerix 3D Scaffolds 28110.73.4 RollerCell 40 28110.74 Tengion, Inc. 28210.74.1 Tengion's Scientific Platform 28210.74.2 Tengion's Pipeline 28310.75 TiGenics NV 28310.75.1 ChondroCelect 28410.75.2 CX601 28410.75.3 Cx611 28510.75.4 Cx621 28510.76 Tissue Genesis, Inc. 28510.76.1 Clinical Therapies from Tissue Genesis 28510.76.1.1 Icellator 28610.76.1.2 Adipase 28610.77 Thermogenesis Corp. 28610.77.1 AXP System 286 10.77.2 MXP System 28710.77.3 Manual Systems 28710.77.4 Res-Q 60 BMC System 28810.77.5 BioArchive System 28810.78 ViaCyte, Inc. 28810.78.1 Technology Overview 28910.79 Vistagen Therapeutics, Inc. 28910.79.1 Vistagen's Technology 28910.79.2 CardioSafe 3D 29010.79.3 LiverSafe 3D 29010.80 Zen-Bio, Inc. 290

Appendix 1: Allogeneic vs. Autologous Stem Cell Therapy 292Appendix 1.1: Manufacturing Process 292Appendix 1.2: Cost Differential 293Appendix 1.3: Donor Screening and Testing 294Appendix 1.4: Release Testing 294Appendix 1.5: Overall Analysis 294

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