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Therapeutic Drug Monitoring Markets

Figure 6.1: Panel of Assays Available for the Abbott iSTAT 81

Figure 7.1: Principle of ELISA 126

Figure 7.2: Enzyme Multiplied Immunoassay Technique (EMIT) 127

Figure 7.3: Flow Diagram of High Pressure Liquid Chromatography 129

Figure 8.1: Market Share Ultra-Large Clinical Chemistry Analyzers U.S. 131

Figure 8.2: Market Share Ultra-Large Clinical Chemistry Analyzers Non-U.S. 131

Figure 8.3: Global Sales of Chemical Analyzers from Roche Diagnostics, 2010 136

Figure 9.1: Summary of Strengths, Weaknesses, Opportunities and Threats of

Therapeutic Drug

Test Market 145

Figure 10.1: Roche Diagnostics Sales Volume, 2008-2012 146

Figure 10.2: Roche Diagnostics Core Operating Profit, 2010-2012 147

Figure 10.3: Roche Diagnostics Sales by Global Region, 2012 148

Figure 10.4: Abbott's Two New Companies in 2012 – Diversified Medical Products

and Research-Based Pharmaceuticals 149

Figure 10.5: Abbott Diversified Medical Product Portfolio 150

Figure 10.6: Abbott Laboratories Global Annual Sales, 2008-2012 150

Figure 10.7: Abbott Laboratories Net Earnings, 2010-2012 150

Figure 10.8: Abbott Laboratories Net Sales – Diagnostics Division, 2010-2012 151

Figure 10.9: Siemens Market Share by Geographic Region, 2012 152

Figure 10.10: Thermo Fisher Revenue Generated by Geographic Region, 2011 152

Figure 10.11: Beckman Coulter Revenue by Geographic Region, 2010 154

Figure 10.12: Beckman Coulter Revenue by Segment, 2010 155

Figure 10.13: Revenue Generated by OraSure's Oral Fluid Collection Devices,

2010-2011 157

Figure 10.14: Bayer Company Structure – Health Care, Crop Science and Material

Science 160

Figure 10.15: Bayer Global Sales by Geographic Market, 2011 162

Figure 10.16: BioRad Global Net Sales, 2007-2011 164

Figure 10.17: BioRad Geographical Breakdown of Sales, 2011 164

Figure 10.18: Research and Development Expenditure, BioRad 2007-2011 165

Figure App 1.1: Volume of Distribution of Various Therapeutic Drugs 167

Figure App 1.2: Major Pharmacokinetic Processes Affecting Drug Concentration 168

Figure App 1.3: Role of Cytochrome P450 Enzymes in Hepatic Metabolism – Relative

Hepatic Content

of CYP Enzyme 169

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